cyclo(-RGDyK)

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抑制剂描述：

产品名称：cyclo(-RGDyK)

产品别名：见爱必信官网

英文别名：cyclo(-RGDyK)

靶点：Integrin

CAS：250612-42-1

纯度：>98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.

溶解性：DMSO 100 mg/mL (117.96 mM)
Water 100 mg/mL (117.96 mM)
Ethanol 20 mg/mL (23.59 mM)

体外研究：

Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM).

体内研究：In apoE?/? mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery.

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