Dyngo-4a

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产品名称：Dyngo-4a

产品别名：见爱必信官网

英文别名：Dyngo-4a

靶点：Dynamin

CAS：1256493-34-1

纯度：≥95%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Dyngo-4a is a potent <b>dynamin</b> inhibitor with <b>IC50</b> of 0.38 μM, 1.1?μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively.

溶解性：DMSO ：67 mg/mL (198.04 mM)

体外研究：

Dyngo-4a inhibits dynamin-dependent endocytosis of transferrin in multiple cell types with IC?? of 5.7 μM, and reduces synaptic vesicle endocytosis and activity-dependent bulk endocytosis in cultured neurons and synaptosomes. In motor nerve terminals and cultured hippocampal neurons, Dyngo-4a blocks Alexa Fluor 488-BoNT/A-Hc internalization. In Drosophila S2R+ cells, Dyngo-4a causes a decrease in the level of Armadillo/β-catenin.

体内研究：

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