LMP744 hydrochloride

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抑制剂描述：

产品名称：LMP744 hydrochloride

产品别名：见爱必信官网

英文别名：LMP744 hydrochloride

靶点：Topoisomerase

CAS：308246-57-3

纯度：

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.

溶解性：

体外研究：

The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM.LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.Cell Cytotoxicity AssayCell Line:P388 and P388 Top1-deficient murine leukemia cells.Concentration:0.1-100 μMIncubation Time:3 daysResult:Induced dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.

体内研究：The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM.LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.Cell Cytotoxicity AssayCell Line:P388 and P388 Top1-deficient murine leukemia cells.Concentration:0.1-100 μMIncubation Time:3 daysResult:Induced dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.

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