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当前位置: 爱必信 > 生物分子 > Pixantrone dimaleate

Pixantrone dimaleate

供货周期: 一周
品牌: 爱必信
规格: >98%
货号: abs817516
CAS号: 144675-97-8
报价: ¥707
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抑制剂描述:

产品名称:Pixantrone dimaleate

产品别名:见爱必信官网

英文别名:Pixantrone dimaleate

靶点:Topoisomerase

CAS:144675-97-8

纯度:>98%

外观:见爱必信官网

保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述:

Pixantrone is a novel aza-anthracenedione compound with antitumor activity. It is a weak topoisomerase II inhibitor and forms stable DNA adducts through alkylation with specificity for DNA hypermethylated sites.

溶解性:DMSO :100 mg/mL (179.37 mM)
Water :100 mg/mL (179.37 mM)

体外研究:

Pixantrone dimaleate is a topoisomerase II inhibitor. Pixantrone induces cell death in multiple cancer cell lines independent of cell cycle perturbation, with IC50s of 37.3 nM, 126 nM and 136 nM for T47D, MCF-10A and OVCAR5 cells, respectively. Pixantrone induces DNA damage at high concentrations (500 nM) but not at concentrations (100 nM) sufficient to kill PANC1 cells. Pixantrone (25 or 100 nM) induces severe chromosomal aberrations and mitotic catastrophe in PANC1 cells. Pixantrone (100 nM) may disrupt chromosome segregation because of generating merotelic kinetochore attachments that cause chromosome non-disjunction. Pixantrone potently inhibits growth of human Leukemia K562 cells, etoposide-resistant K/VP.5 cells, MDCK and ABCB1-transfected MDCK/MDR cells, with IC50s of 0.10 μM, 0.56 μM, 0.058 μM and 4.5 μM, respectively. Pixantrone (0.01-0.2 μM) leads to a concentration-dependent formation of linear DNA through acting on topoisomerase IIα. Pixantrone produces semiquinone free radicals in an enzymatic reducing system, although not in a cellular system, most likely due to low cellular uptake. Pixantrone (0.01-10 μM) shows potent inhibitory activities against rat 97-116 peptide-specific T cell proliferation.

体内研究:Pixantrone (27 mg/kg) does not worsen pre-existing moderate degenerative cardiomyopathy in doxorubicin-pretreated mice, by i.v. one dose every 7 days repeated thrice (q7d × 3). Pixantrone (27 mg/kg) causes minimal cardiotoxic in mice following repeated treatment cycles. Moreover, Pixantrone results in less mortality than mitoxantrone in doxorubicin-pretreated mice. Pixantrone (16.25 mg/kg i.v, q7d × 3) modulates Lymph node cells (LNC) responses, and affacts T cell subpopulations in TAChR-immunized Lewis rats. Pixantrone also shows preventive and therapeutic effect in experimental autoimmune myasthenia gravis (EAMG) rats.

产品信息订购:

  产品货号   产品名称   规格 价格 大包装及货期
  abs817516   Pixantrone dimaleate   5mg   707.00   立即咨询
  abs817516   Pixantrone dimaleate   10mg   1178.00   立即咨询
  abs817516   Pixantrone dimaleate   25mg   2053.00   立即咨询
  abs817516   Pixantrone dimaleate   100mg   3567.00   立即咨询

产品更多信息请进入爱必信网站咨询

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企业名称

爱必信(上海)生物科技有限公司

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信用代码

913101155665500522

成立日期

2010-12-13

注册资本

2500

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Pixantrone dimaleate由爱必信(上海)生物科技有限公司为您提供,货号abs817516,规格:>98%,CAS号:144675-97-8,如您想了解更多关于Pixantrone dimaleate价格、Pixantrone dimaleate结构式、批发、用途等信息,欢迎咨询。除供应Pixantrone dimaleate外,还可为您提供潮霉素B,Hygromycin B,absin品牌、细胞膜荧光探针DiO, DiO细胞膜染料、游离DNA提取试剂盒等试剂,公司有专业的客户服务团队,是您值得信赖的合作伙伴,爱必信客户服务电话,售前、售后均可联系。
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