Embelin

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抑制剂描述：

产品名称：Embelin

产品别名：见爱必信官网

英文别名：Embelin

靶点：Quinones

CAS：550-24-3

纯度：99%

外观：见爱必信官网

保存方法：Store at -20℃

描述：

Embelin，从矮地茶中分离的一种醌类化合物，是一种细胞凋亡的X染色体抑止剂(XIAP)的抑制剂，无细胞试验中IC50为4.1 μM。

溶解性： DMSO 29.4 mg/mL (100 mM)
Ethanol : 2.9 mg/mL (10 mM), with gentle warming

体外研究：

Embelin from the Japanese Ardisia herb is a small-molecular inhibitor that binds to the XIAP BIR3 domain with which Smac and caspsase-9 bind. Embelin inhibits cell growth of both PC-3 and LNCap cells in a dose-dependent manner, with IC50 values of 3.7 and 5.7 μM. While, the toxicity of Embelin in normal PrEC and in WI-38 cells is much lower with IC50 values of 20.1 μM and 19.3 μM. Treatment of PC-3 cells with 25 and 50 μM of embelin for 48 h, 30% and 75% of cells undergo apoptosis, representing approximately 3-and 9-fold increase as compared to untreated cells. Embelin also potently suppresses the biosynthesis of eicosanoids by selective inhibition of 5-lipoxygenase (5-LO) and Microsomal prostaglandin E2 synthase-1 (mPGES-1) with IC50 = 0.06 and 0.2 mM, respectively.

体内研究：

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