Lauric Acid

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抑制剂描述：

产品名称：Lauric Acid

产品别名：见爱必信官网

英文别名：Lauric Acid

靶点：Miscellaneous

CAS：143-07-7

纯度：＞98%

外观：见爱必信官网

保存方法：Store at -20°C

描述：

Lauric Acid，which is found naturally in various plant and animal fats and oils， is a saturated medium-chain fatty acid with a 12-carbon backbone. It is a major component of coconut oil and palm kernel oil.

溶解性：DMSO : 38 mg/mL (189.7 mM)
Ethanol : 38 mg/mL (189.7 mM)
Water : 16 mg/mL (79.9 mM)

体外研究：

Previous study showed that lauric acid could induce apoptosis in both Caco-2 and IEC-6 cells when compared to butyrate. Moreover, lauric acid reduced GSH availability and generated ROS in Caco-2 cells. Mechanistic study indicated that lauric acid reduced Caco-2 and IEC-6 cells in G0/G1and arrested cells in the S and G2/M phases. In addition, it was found that butyrate protected IEC-6 cells from ROS-induced damage, while lauric acid induced higher levels of ROS when compared with butyrate.

体内研究：Mouse in vivo study found that both epicutaneous application and intradermal injection of lauric acid could decrease the number of P. acnes colonized in mouse ears effectively, thus relieving P. acnes-induced granulomatous inflammation and ear swelling.

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