Astragaloside A

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抑制剂描述：

产品名称：Astragaloside A

产品别名：见爱必信官网

英文别名：Astragaloside A

靶点：Miscellaneous

CAS：83207-58-3

纯度：＞98%

外观：见爱必信官网

保存方法：-20°C

描述：

黄芪甲苷Astragaloside A 是黄芪在中医的主要活性成分；已广泛用于治疗缺血性疾病

溶解性：DMSO ：93 mg/mL (118.5 mM)

体外研究：

Astragaloside IV improves post-ischemic heart function and ameliorated reperfusion arrhythmias accompanied by a significant increase in myocardial antioxidative enzyme superoxide dismutase activity in rat hearts in vitro. While, Astragaloside IV's protective effect on heart function can be partially abrogated by the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methyl ester.

体内研究：Astragaloside IV significantly reduces infarct size in dogs subjected to coronary ligation in vivo. Astragaloside IV attenuates isoproterenol-induced subendocardial necrosis, serum lactate dehydrogenase and creatine kinase activation, and lipid oxide product malondialdehyde formation in rats. It also reduces sarcoplasmic reticulum Ca(2+)-uptake ability and Ca(2+)-ATPase (SERCA2a) activity as well as SERCA2a mRNA expression in myocardial injury rats.

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