Oligomycin A

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抑制剂描述：

产品名称：Oligomycin A

产品别名：见爱必信官网

英文别名：Oligomycin A

靶点：Miscellaneous

CAS：579-13-5

纯度：＞98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Oligomycin A是一种ATP synthase抑制剂，作用于线粒体膜的耦合作用，抑制氧化磷酸化和ATP依赖性的反应。

溶解性：DMSO ：15 mg/mL (18.96 mM)

体外研究：

Oligomycin A is a mitochondrial F0F1-ATPase inhibitor with a Ki of 1 μM. Oligomycin A shows cytotoxic to the NCI-60 cell lines, with GI50 of 10 nM. Oligomycin A also inhibits the activity of Triton X-100-solubilized ATPase with a Ki of 0.1 μM. Furthermore, Oligomycin A has anti-fungal activity. Oligomycin A (2.4?μM) inhibits the ability of spermatozoa to achieve feasible in vitro capacitation (IVC), and also suppresses progesterone-induced in vitro acrosome exocytosis (IVAE) as well as the concomitant peaks of O2 consumption and ATP levels.

体内研究：

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