Xylitol is reported to have an inhibitory effect on LPS-induced inflammatory cytokine expression. Xylitol strongly inhibits tube formation, migration, and invasion of HUVECs. Xylitol decreases the mRNA expression of key angiogenic molecules and their receptors (VEGF, KDR, bFGF and bFGFR-II) in a dose-dependent manner. Also, it suppresses NF-κB and Akt activation of HUVECs.
体内研究:Xylitol triggers the release of insulin in dogs and inhibits in vivo angiogenesis. It prominently inhibits the formation of neo-microvessels in the Matrigel assay, and reduces the hemoglobin content in the Matrigel plug.