Arctigenin

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产品名称：Arctigenin

产品别名：见爱必信官网

英文别名：Arctigenin

靶点：Lignans

CAS：7770-78-7

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20° C

描述：

Arctigenin is a dibenzyl butyrolactone lignan agent with antiinflammatory and antioxidant properties. Studies describe arctigenin to potently block TNF- α production and NO secretion. MAP kinase studies show that arctigenin effectively inhibits the activity of MAP kinases and AP-1 activation through vigorous inhibition of MKK. Additional studies report that arctigenin acts as a potent inhibitor of PAC-1 activity. Arctigenin has also been shown to bind to kainic acid receptors and protect neurons from neurodegeneration induced by glutamate and inhibit HIV-1 integrase. Furthermore, this compound acts as an inhibitor of IκB phosphorylation. Arctigenin is an inhibitor of MEK-1 and Topo II.

溶解性：DMSO : 37.2 mg/mL (100 mM)

体外研究：

Arctigenin induces apoptosis in HT-29 colon cancer cells by regulating ROS and p38 MAPK pathways. It is a phytoestrogen that exerts a proliferative effect by binding to the ER. Treatment with arctigenin effectively downregulates ERα expression. Thus, arctigenin, mainly targets the mTOR pathway in ERα-positive MCF-7 human breast cancer cells, leading to autophagy-induced cell death and the downregulation of ERα expression. Arctigenin decreases BACE1 translation via dephosphorylation of eIF2α, causing the suppression of Aβ production, and initiates autophagy through both AMPK/Raptor signaling activation and AKT/mTOR pathway inhibition, resulting in enhanced Aβ clearance. Arctigenin suppresses BACE1 activity via inhibition of BACE1 translation.

体内研究：Treatment of arctigenin in mice highly decreases Aβ formation and senile plaques and efficiently ameliorates AD mouse memory impairment of APP/PS1 transgenic model mice.

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