Puerarin

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抑制剂描述：

产品名称：Puerarin

产品别名：见爱必信官网

英文别名：Puerarin

靶点：Flavonoids

CAS：3681-99-0

纯度：99%

外观：见爱必信官网

保存方法：-20°C

描述：

 Puerarin 是一种5-HT2C受体和苯二氮位点拮抗剂。

溶解性：DMSO：86 mg/mL (206.54 mM)

体外研究：

Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. Pueraria is employed clinically to treat cardiovascular diseases in China. Another study showed that puerarin also possessed anti-cancer properties. Puerarin at 25 μM dose-dependently reduces HT-29 cellular growth with an increase of bax and decreases of c-myc and bcl-2.

体内研究：In hypercholesterolmic diet plus administration of puerarin (300 mg/kg/day, p.o.) rats, Puerarin markedly attenuated the increased total cholesterol induced by hypercholesterolmic diet in both serum and liver. LD50: Mice 738mg/kg (i.v.)

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