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Tanshinone IIA

供货周期: 一周
品牌: 爱必信
规格: >98%
货号: abs819491
CAS号: 568-72-9
报价: ¥578
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抑制剂描述:

产品名称:Tanshinone IIA

产品别名:见爱必信官网

英文别名:Tanshinone IIA

靶点:Diterpenoids

CAS:568-72-9

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20° C

描述:

Tanshinone IIA (Tan IIA) is one of the main fat-soluble compositions in the root of red-rooted salvia. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. 

溶解性:DMSO : 3.85 mg/mL (13.08 mM; Need ultrasonic)

体外研究:

The anti-tumor effect of Tanshinone IIA includes inhibiting tumor cell proliferation, disturbing tumor cell cycle, promoting tumor cell apoptosis, and inhibiting tumor cell invasion and transfer. Tanshinone IIA has anti-proliferative effects on A549 cells: the IC50 of Tanshinone IIA after 24, 48 and 72 h are 145.3, 30.95 and 11.49 μM, respectively. The CCK-8 assay is used to evaluate the proliferative activity of A549 cells treated with Tanshinone IIA (2.5-80 μM) for 24, 48 and 72 h, respectively. The CCK-8 results show that Tanshinone IIA can significantly inhibit A549 cell proliferation in a dose- and time-dependent manner. Obvious apoptosis and cell growth inhibition of A549 cells are observed after drug treatment for 48 h (concentrations used are approximately IC50 values: Tanshinone IIA 31 μM on A549). Western blotting finds that 48 h exposures to Tanshinone IIA (31 μM) in A549 cells, downregulates expression of VEGF and VEGFR2 protein in both drug treatment groups vs. vehicle. Tanshinone IIA, one of the most abundant constituents of the root of Salvia miltiorrhiza, protects rat myocardium-derived H9C2 cells against apoptosis. Treatment of H9C2 cells with Tanshinone IIA inhibits angiotensin II-induced apoptosis by downregulating the expression of PTEN (phosphatase and tensin homolog), a tumor suppressor that plays a critical role in apoptosis. Tanshinone IIA inhibits angiotensin II (AngII)-induced apoptosis by downregulating the expression of phosphatase and tensin homolog (PTEN). Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells.

体内研究:

产品信息订购:

  产品货号   产品名称   规格 价格 大包装及货期
  abs819491   Tanshinone IIA   10mg   578.00   立即咨询
  abs819491   Tanshinone IIA   50mg   1943.00   立即咨询

产品更多信息请进入爱必信网站咨询

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企业名称

爱必信(上海)生物科技有限公司

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信用代码

913101155665500522

成立日期

2010-12-13

注册资本

2500

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Tanshinone IIA由爱必信(上海)生物科技有限公司为您提供,货号abs819491,规格:>98%,CAS号:568-72-9,如您想了解更多关于Tanshinone IIA价格、Tanshinone IIA结构式、批发、用途等信息,欢迎咨询。除供应Tanshinone IIA外,还可为您提供百日咳毒素兔多抗,HRP标记、胶原酶 II型;蛋白水解酶、丝状血凝素粘附素FHA兔多抗,HRP标记等试剂,公司有专业的客户服务团队,是您值得信赖的合作伙伴,爱必信客户服务电话,售前、售后均可联系。
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