Vinorelbine

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抑制剂描述：

产品名称：Vinorelbine

产品别名：见爱必信官网

英文别名：Vinorelbine

靶点：Alkaloids

CAS：71486-22-1

纯度：>98%

外观：见爱必信官网

保存方法：Store at -20°C

描述：

Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase.

溶解性：DMSO : 100 mg/mL
Water : 100 mg/mL

体外研究：

Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase. Vinorelbine time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner.

体内研究：After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth(1) vinorelbine treatment in the dogs. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m2.

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