SBE 13 HCl

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抑制剂描述：

产品名称：SBE 13 HCl

产品别名：见爱必信官网

英文别名：SBE 13 HCl

靶点：PLK

CAS：1052532-15-6

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：SBE13 hydrochloride is a potent and selective PLK1 with IC50 of 0.2 nM; no inhibition om Aurora A kinase, Plk2 and Plk3.

溶解性：10 mM in water;100 mM in DMSO; 10 mM in ethanol

体外研究：

SBE 13 decreases cell proliferation in various cancer cell lines, and causes a G2/M arrest followed by apoptosis. In primary cells, SBE 13 does not impair cell cycle and thus proliferation of primary cells. SBE13 in combination with Enzastaurin displays a synergistic reduction of cell proliferation and enhanced apoptosis induction in HCT116(p53-/-) cells.

体内研究：

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