FRAX1036

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抑制剂描述：

产品名称：FRAX1036

产品别名：见爱必信官网

英文别名：FRAX1036

靶点：PAK

CAS：1432908-05-8

纯度：＞98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

FRAX1036是新型ATP竞争性的PAK小分子抑制剂。

溶解性：DMSO : 5.3 mg/mL (Need warming)

体外研究：

Potent cellular inhibition of group I PAK substrate phosphorylation (MEK1-S298 and CRAF-S338) was observed at 2.5 to 5 μM concentrations of FRAX1036 in PAK1-amplified MDA-MB-175 cells. Treatment of PAK1-amplified breast cancer cells with FRAX1036 results in apoptosis. And treatment of OVCAR-3 cells with FRAX-1036 results in upregulation of p53 and p21, while down-regulating cyclin B1.

体内研究：Treatment with Frax1036 results in slower KT21 tumor growth and is unlikely to have significant blood brain barrier permeability in mice.

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