eIF4A3-IN-2

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抑制剂描述：

产品名称：eIF4A3-IN-2

产品别名：见爱必信官网

英文别名：eIF4A3-IN-2

靶点：eif;Autophagy

CAS：2095677-20-4

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.

溶解性：In Vitro: DMSO : 100 mg/mL (165.92 mM; Need ultrasonic)

体外研究：

eIF4A3-IN-2 (compound 2) binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and cellular nonsense-mediated RNA decay (NMD) activities.Apoptosis AnalysisCell Line:HEK293T cells (transfected with the NMD reporter) luciferase assayConcentration:0.3, 1, 3, or 10 μMIncubation Time:3 or 6 hResult:eIF4A3-IN-2 induces an approximately 3.2-fold increase in luciferase activity, indicating that NMD is inhibited by compound 2.

体内研究：

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