保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
描述:
LY2606368 is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.
溶解性:DMSO: ≥ 60 mg/mL
体外研究:
体内研究:LY2606368 (15 mg/kg, s.c.) significantly inhibits tumor growth in xenograft tumor models with less animal weight loss. LY2606368 (2 mg/kg, s.c.) and BMN673 combination has synergistic anticancer effect in gastric cancer PDX model, and the effect is higher than that of one drug alone.