Utilization-of-SFC-for-Chiral-Structural-Analysis
2019-05-21 17:42
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资料摘要:
The methods of generating enantiomers are classified roughly into asymmetric synthesis,
crystallization, enzyme reaction, and optical resolution by chromatography. In particular, normal
phase chromatography with chiral stationary phases has been used in various fields such as
pharmaceuticals, agrichemicals, natural products, biomolecules, and functional materials
because of the cost efficiency. Recently, preparative SFC, which provides faster, higherseparation analysis and easier post handling of fractions than HPLC, has become a main stream
as an efficient method of producing enantiomers in the drug discovery stage
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