本文介绍了使用开发的SFC方法尼古丁的异构体分析 关键词：烟草、尼古丁、SFC、快速LC、E-液体、对映体

CD光谱法是一种适用于蛋白质HOS评估的技术

本申请描述了使用带有Clear view“ATR物镜（ATR-5000-ss）和 IQ Mapping的IRT-5200显微镜测量洗面奶糊状填充物中发现的黑色颗粒。

关键词：生物制药，抗体药物，FDS，聚集物，蛋白质降解产物，MabThera®，Tskgel G3000SWXL，SEC，紫外检测器，蛋白质聚集

关键词： HPLC, Chromatography, Amygdalin, Neoamygdalin, Cyanogenic Glycosides, Rosaceae, Seeds, Chiral, Epimer, Vitamin B17

关键词：微塑料，降解塑料，机器学习，高级光谱搜索，红外塑料库

在本研究中，基于CD光谱监测CBN结合DNA适体的结构变化。结构变化被评估为配体CBN、温度和其他类型的大麻素、大麻素二醇（CBD）和大麻素醇（CBG）的函数。CD光谱测量采用J-1500型CD光谱仪与HTCD Plus全自动CD测量装置相结合。该系统允许在一次运行中对多达192个样本进行自动CD光谱测量，使其非常适合于候选DNA适体的早期筛选。

关键词：抗抑郁药物降解、改性钛硅酸盐、organotriethoxysilanes, 太阳辐射下的光催化

本文介绍了用红外成像显微镜对微塑料进行颗粒分析的结果。 关键词：100-MT-0262，FTIR显微镜，微塑料，颗粒分析，颗粒分布，直方图

关键词：747022G, Antibody, IgG, Antibody Drug, Biopharmaceutical, Aggregate, TSKgel G3000SWXL, SEC, UV 检测器

关键词：Allethrin-isomers，Pyrethoid，Pesticide，HPLC，RHPLC，CD Chiral，Insecticide，Allethrin，

本应用中报告了同步分析的结果，测量了一种市售防晒霜中紫外线吸收的11种成分。 关键词：920014X，HPLC，PDA检测器，紫外线吸收，防晒霜，C8，EXTREMA

本应用中简述了JASCO开发了清晰视野™ATR物镜，可以使用单个卡塞格伦物镜观察样品并进行ATR光谱测量。

本应用中描述了CD光谱法在高浓度抗体（未稀释）中的扩展应用，并报告了使用Spectra Manager Ver.2.5 CFR Bestsel对抗体药物进行详细二级结构评估的结果。

在本研究中，基于CD光谱监测CBN结合DNA适体的结构变化。结构变化被评估为配体CBN、温度和其他类型的大麻素、大麻素二醇（CBD）和大麻素醇（CBG）的函数。CD光谱测量采用J-1500 CD光谱仪与HTCD Plus自动CD测量装置相结合。该系统允许在一次运行中对多达192个样本进行自动CD光谱测量，使其非常适合于候选DNA适体的早期筛选。

Terpenes in essential oils are easily oxidized and can cause a decrease in the flavor in foods. Removal of Terpenes is commonly practiced in perfume industry to yield higher quality oils. Natural spearmint oilcontains l-limonene that is quite unlike d-limonene, the aroma is not reminiscent of citrus but of a light, clean Terpene hydrocarbon fragrance. Conventionally, Terpenes are removed using vacuum distillation. However, it is difficult to monitor the fractionation process in real-time during this process. We used SFC with a PDA detector and an FTIR spectrometer as a dual monitoring system to enable selective monitoring of the target compound Carvone in real time during elution and fractionation. The PDA provides broad information on the separation, but cannot differentiate between limonene and Carvone.

It is generally understood that chiral compounds have different bioactivities depending upon the absolute configuration of each compound. Some familiar examples include glutamic acid and thalidomide. Lglutamic acid demonstrates the “Umami” taste*1, while D-glutamic acid has a bitter taste, similarly, the R form of thalidomide is a sedative, but the S form has teratogenic activity. Thus, the separation and study of chiral compounds is critical for many reasons. The functionalities of chiral compounds have been studied for the development of advanced molecules for many applications. The study of chiral compounds has spread to several fields such as natural products, pharmaceuticals and other functional molecules, and it can be pointed out that among those studies, the structural analysis of chiral compounds is a very important topic. X-ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR) and Electronic Circular Dichroism (ECD) using UV/Vis light are employed as primary methods for the structural analysis of chiral compounds. In this paper, the measurement of chiral compounds by Vibrational Circular Dichroism (VCD) using infrared light will be outlined. VCD is a method to measure the difference of absorbance intensity between left-hand and right-hand circularly polarized light as shown in Figure 1. It is an advantage of VCD that this method can be applied to almost all organic compounds in the same way as infrared (IR) spectroscopy. In addition, by comparing the measurement results with calculated results by ab-initio molecular orbital calculations, the absolute configuration of the sample can be determined. However, since the peak intensity of VCD spectra are 1,000 – 10,000 times weaker than that of standard IR spectra, spectroscopic instruments with high sensitivity and stability with very small baseline fluctuations are required. The FVS-6000 VCD system has a high sensitivity detector, suitable optical

Introduction Generally, a sample for CD measurement needs to be in a liquid state to allow transmission measurement, more recently there has been increasing requirement for CD measurement of samples that are insoluble or may change structure in solution. These types of sample are best measured in solid state. Although CD measurement can be made in transmission for solid samples, there is a requirement for sample preparation; such as making a pellet and if sample dilution is required, sample recovery can be difficult. As an alternative, measurement using Diffuse Reflection (DR) CD is recommended. 1), 2) This application note illustrates the use of DRCD measurement with the DRCD-575 diffuse reflectance accessory (See Fig. 1.) optimized for the J-1500 CD spectrometer with the multi-probe simultaneous CD/LD measurement. DRCD uses incident light to illuminate a solid sample and

关键词：蛋白质二级结构，FTIR，transmission cell，SSE测定，酰胺带，α-螺旋，beta sheet, beta turn，溶菌酶，血细胞凝集素

全真空FT/IR气体分析系统（N2气体中微量水）。本申请说明中介绍的全真空气体分析系统在样品室中集成了一个特殊的气室，使整个光路在气室就位的情况下保持在全真空下。

红外定量分析是分析实验室的日常需求。虽然液体溶液是一种常见的样品，但也存在粉状成分的混合物，通常希望获得不溶解到溶剂中的定量结果。本文概述了两种粉状混合物的定量分析方法的发展。

用NIR成像法鉴定药片

与中红外分析相比，近红外（NIR）光谱具有独特的能力，中红外分析通常需要大量的样品制备才能获得可识别的光谱。因此，根据所需的分析，NIR可用于特定样品区域的非破坏性分析或提供较大样品区域的平均值。近年来，近红外光谱已被广泛用于生物样品的检测以及食品和医疗产品的质量控制/分析。漫反射技术是这种方法的理想选择，因为样品处理极其简单，因此可以通过使用使用近红外漫反射创建的搜索数据库来快速识别非法药物，如MDMA。

对于低浓度气体或蒸汽化合物的FT-IR分析，通常需要高信噪比测量。此外，某些气体样品的测量可能会受到仪器中存在的大气水蒸气和二氧化碳的影响，即使是通过氮气净化。由于NO气体的吸收带在水蒸气区，而二氧化氮、二氧化碳和CO气体的吸收带靠近二氧化碳吸收区，因此分析尤其困难。使用全真空仪器系统，可以完全消除光路中的水蒸气和二氧化碳，即使在低浓度下也可以完成这些气体成分的测量。

为了验证各种水电解质溶液中水化和离子之间的关系，我们使用JASCO FT/IR- 6300FV和液体三反射ATR附件对纯水和各种盐水溶液进行了远红外ATR测量。

使用65度入射角ATR评价硅晶片表面

利用红外光谱，通过在光路中放置偏振器测量样品的偏振特性来评估取向。已经开发了一种偏振ATR配件，可以基于ATR效应测量样品偏振，并可以分析1-2µm范围内样品表面的分子取向。该技术允许分析样品表面的分子取向，而不考虑样品厚度或材料。

FT IR-4000和FT IR 6000系列FTIR仪器验证软件，Spectra Manager II软件包括一个仪器验证包，可用于评估FT/IR-4000/6000紫外-可见光谱仪器的性能。

红外光谱可用于识别特定化合物或化合物混合物

JASCO IRT-5000/7000系列FT-IR显微镜系统能够将系统从基本的单元件探测器显微镜附件不断升级为多元件探测器成像系统。数据收集和分析软件包为从各种类型的样本中收集数据提供了广泛的选项，并提供了大量的样本数据可视化功能。显微镜可以添加到JASCO FT/IR-4000或FT/IR-6000系列仪器中，提供从最基本的仪器平台到研究级光谱仪的显微镜或成像能力。IRT-5000/7000有多种选择，可以根据用户的指定提供显微镜和/或成像，只提供购买时所需的物品，但可以随时升级以扩展显微镜系统的功能。