细胞分化蛋白SEPT12抗体

英文名称  Anti-SEPT12 

中文名称  细胞分化蛋白SEPT12抗体 

细胞分化蛋白SEPT12抗体别    名  SEPT12; SEPT 12; SEP12_HUMAN; Septin-12; Septin 12; Septin12. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg   

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, Zebrafish  

产品类型  一抗    

研究领域  细胞生物 细胞周期蛋白 细胞分化 细胞骨架  

蛋白分子量  predicted molecular weight: 41kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human SEPT12 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

细胞分化蛋白SEPT12抗体储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis.

Function : Filament-forming cytoskeletal GTPase (By similarity). May play a role in 细胞分化蛋白SEPT12抗体cytokinesis (Potential). 

Subunit : Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPT6 and SEPT11. Forms homodimers.

Subcellular Location : Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell projection, cilium, flagellum. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus.

Tissue Specificity : Widely expressed.

DISEASE : Defects in SEPT12 are the cause of spermatogenic failure 10 (SPGF10) [MIM:614822]. An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. The most prominent feature is a defective sperm annulus, a ring structure that demarcates the midpiece and the principal piece of the sperm tail.

Similarity : Belongs to the septin family. 

Database links : UniProtKB/Swiss-Prot: Q8IYM1.1

SEPTIN(SEPT)家族是细胞骨架蛋白的一种，具有GTPase的活性。经研究发現，SEPT参与细胞核分裂、细胞膜的运输以及构成细胞骨架。