突触结合蛋白11抗体

英文名称  Anti-Synaptotagmin XI 

中文名称  突触结合蛋白11抗体 

突触结合蛋白11抗体别    名  Synaptotagmin 11; Synaptotagmin 12; Synaptotagmin XI; Synaptotagmin-11; synaptotagmin XII; synaptotagmin-XII; Synaptotagmin11; Synaptotagmin12; Synaptotagmin-11; Synaptotagmin-12; SynaptotagminXI; SYT 11; SYT 12; SYT-11; SYT-12; Syt XI; Syt11; SYT11_HUMAN; SYT12; SytXI; DKFZp781D015; KIAA0080; MGC10881; MGC17226. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg   

抗体来源  Rabbit  

克隆类型  polyclonal 

突触结合蛋白11抗体交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep

产品类型  一抗    

研究领域  细胞生物 神经生物学 信号转导  

蛋白分子量  predicted molecular weight: 48kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human Synaptotagmin XI (51-100aa) 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Synaptotagmins are a large family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Synaptotagmin XI, also known as SYT11 (Synaptotagmin-11), is a 431 amino acid protein that localizes to the membrane and is expressed ubiquitously with highest expression in brain and lung. Like other Synaptotagmin proteins, Synaptotagmin XI is involved in the calcium-dependent exocytosis of secretory vesicles and is thought to act as a calcium sensor during vesicular trafficking. Synaptotagmin XI contains two C2 domains through which it can bind either three calcium ions or the zinc-finger protein Parkin (a juvenile Parkinson’s disease gene product), the latter of which causes the polyubiquitination and subsequent degradation of Synaptotagmin XI by the proteasome complex. Defects in the gene encoding Synaptotagmin XI are implicated in a number of neurological disorders, including schizophrenia and Parkinson’s disease.

Function : May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Subunit : Homodimer. Can also form heterodimers. Interacts with PARK2.

Subcellular Location : Membrane; Single-pass membrane protein. Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.

Post-translational modifications : Ubiquitinated and targeted to the proteasome complex for degradation.

突触结合蛋白11抗体Similarity : Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Database links : UniProtKB/Swiss-Prot: Q9BT88.2