磷酸化Src原癌基因抗体
产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
磷酸化Src原癌基因抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 (石蜡切片需做抗原修复)
磷酸化Src原癌基因抗体
产品介绍
Src (also known as pp60src) is a non receptor Tyrosine Kinase involved in signal transduction in many biological systems and implicated in the development of human tumors. There are two critical phosphorylation sites of tyrosine on Src, tyrosine 418 and tyrosine 529 (referring to human Src sequence). The tyrosine 418 is located in the catalytic domain and is one of the autophosphorylation sites. Full catalytic activity of Src requires phosphorylation of tyrosine 418. The tyrosine 529 is located near the carboxyl terminus of Src and acts as a negative regulator, in that Src is held in the inactive form through an intramolecular interaction between the SH2 domain and the carboxyl terminus when tyrosine 529 is phosphorylated by Csk. This conformation blocks phosphorylation of tyrosine 418 at the catalytic domain, thereby preventing Src activation. When tyrosine 529 is dephosphorylated, tyrosine 418 can be maximally phosphorylated and Src becomes active. Src is a proto oncogene that may play a role in the regulation of embryonic development and cell growth. Mutations in this gene could be involved in the malignant progression of colon cancer.
Immunogen: Synthetic peptide (Human) derived from the region of Src that contains tyrosine 529, based on the human sequence. The sequence is conserved in mouse (tyrosine 534), chicken (tyrosine 527) and frog (tyrosine 525).
mol wt:60kDa
Other Aliases:
Rous sarcoma oncogene; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); ASV; Avian sarcoma virus; c SRC; CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA; cSrc; EC 2.7.10.2; Neuronal CSRC tyrosine specific protein kinase; Neuronal SRC; Oncogene SRC; OTTHUMP00000030931; OTTHUMP00000174476; OTTHUMP00000174477; p60 Src; p60Src; pp60c src; pp60csrc; Proto oncogene tyrosine protein kinase Src; Protooncogene SRC; protooncogene SRC Rous sarcoma; SRC Oncogene; SRC1; Tyrosine kinase pp60c src; Tyrosine protein kinase SRC1; v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian; vsrc avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog
xy-2681R NKp80细胞毒性受体NK-p80抗体
xy-2679R CD112细胞粘附分子CD112抗体
xy-10233R Nephrin肾小球细胞粘附分子受体抗体
xy-10444R NR5A2/LRH1成纤维细胞核受体Nr5a2抗体
磷酸化Src原癌基因抗体
xy-1550R NCX1钠钙交换蛋白1抗体
xy-2057R NCX3钠钙交换蛋白3抗体
xy-2030R NMDAR1天冬氨酸受体抗体
xy-2013R phospho-Nrf2 (Ser40)磷酸化核因子2相关因子2(Ser40)抗体
xy-10420R Nemo-like kinaseNemo样激酶抗体
xy-10421R Phospho-Nemo-like kinase (Thr298)磷酸化Nemo样激酶抗体
xy-10402R phospho-NIFK (Thr238)磷酸化NIFK抗体
xy-10401R phospho-NIFK (Thr230)磷酸化NIFK抗体
xy-13693R NCKAP5NCKAP5蛋白抗体
xy-13694R NOSTRIN一氧化氮合酶转运诱导抗体
xy-13656R NSMAF中性鞘磷脂相关因子抗体
xy-15592R NFIL3人白介素3介导核因子抗体
xy-13657R NSP3SH2结构域蛋白3A抗体
xy-2464R Neuritin转化神经突起蛋白抗体
xy-13765R NPIP-like protein 1NPIP样蛋白1抗体
xy-6058R Nicastrin老年性痴呆蛋白APH2抗体
xy-6060R NARC1神经细胞凋亡调节转化蛋白1抗体(前蛋白转化酶枯草溶菌素9)
xy-12018R NPFF1 ReceptorG蛋白偶联受体147抗体
xy-3513R Nur77孤儿核受体蛋白Nur77抗体
xy-3313R Phospho-Nur77(Ser351)磷酸化孤儿核受体蛋白Nur77抗体
xy-0452R NAIF1 protein核凋亡诱导因子蛋白1
xy-1067R NMDAR2C谷氨酸受体2C抗体
xy-0175R TrkB酪氨酸激酶B抗体
xy-1091R NADPH oxidase 4NADPH氧化酶4抗体
xy-9316R NDE1核分布基因E同源蛋白1抗体
xy-9317R NEK9丝氨酸/苏氨酸蛋白激酶NEK9抗体
xy-9318R phospho-NEK9(Thr210)磷酸化丝氨酸/苏氨酸蛋白激酶NEK9抗体
xy-9319R NNF1R多胺调控因子1抗体
xy-9300R NNP1新型核蛋白质1抗体
xy-7080R Nucleolar protein 3核仁蛋白3抗体
xy-9625R NPAP1核孔蛋白1抗体
xy-4730R NADPH oxidase 4NADPH氧化酶4抗体
xy-9713R FAD24脂肪细胞分化因子24
xy-9468R Nebulette肌动蛋白结合蛋白Z盘状蛋白抗体
xy-9473R NFAT5活化T细胞核因子5蛋白抗体
xy-9474R phospho-NFAT5 (Ser1197)磷酸化活化T细胞核因子5蛋白抗体
xy-1373R Lipocalin 2脂质运载蛋白抗体
xy-1366R NF22型神经纤维瘤抗体
xy-8513R NIR1膜相关磷脂转运蛋白抗体
xy-0903R Natrexone纳曲酮抗体IgG
xy-3297R Phospho-NDRG1 (Ser330)磷酸化分化相关基因NDRG1抗体
xy-3298R Phospho-NDRG1 (Thr346)磷酸化分化相关基因NDRG1抗体
xy-3506R NEDD4L泛素连接酶NEDD4-2抗体
xy-3291R Phospho-NF2(Ser518)磷酸化2型神经纤维瘤抗体
xy-3302R Phospho-NMDAR1(Ser896)磷酸化谷氨酸受体1抗体
xy-3903R Phospho-NMDAR1 (Ser897)磷酸化谷氨酸受体1抗体
xy-11214R Nfasc186 神经束蛋白186抗体
更多
更多
企业名称
上海信裕生物技术有限公司
企业信息已认证
企业类型
信用代码
310112001202097
成立日期
2012-08-17
注册资本
50
经营范围
上海信裕生物技术有限公司
公司地址
上海市松江区新九广场卖新公路2077号3楼8306室
客服电话