端粒酶抑制因子PinX-1抗体

公司端粒酶抑制因子PinX-1抗体具有高纯度、高效价、高特异性的特点，仅用于科学研究，不可用于临床诊断及药物治疗，可以应用于多种实验。CST、Santa抗体品牌。

英文名称  Anti-PINX-1 

中文名称  端粒酶抑制因子PinX-1抗体

别    名  67-11-3 protein; FLJ20565; Hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; LPTL; LPTS; MGC8850; PIN2 interacting protein 1; Pin2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; PINX1; PINX1_HUMAN; Protein 67-11-3; TRF1-interacting protein 1. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg  0.2ml/200μg
端粒酶抑制因子PinX-1抗体 的相关产品:

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Rabbit Anti-human IgM/AP  碱性磷酸酶（AP）标记的兔抗人IgM 0.1ml

Rabbit Anti-human IgM/APC  APC标记的兔抗人IgM 0.1ml

Rabbit Anti-human IgM/Bio  生物素标记的兔抗人IgM 0.3ml 

端粒酶抑制因子PinX-1抗体抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Pig, Cow, Horse 

产品类型  一抗    

研究领域  肿瘤 细胞生物 转录调节因子  

蛋白分子量  predicted molecular weight: 37kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PINX-1 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 PINX1 is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. PINX1 contains one G-patch domain and one telomeric inhibiting domain (TID) at its C-terminus. PINX1 interacts with the telomere protein TRF1 and the telomerase reverse transcriptase TERT. The TID domain of PINX1 specifically interacts with TERT and functions to inhibit its activity, thus participating in the regulation of telomerase activity. Overexpression of PINX1 leads to shortened telomeres, further supporting an inhibitory role of PINX1 on telomerase activity. The depletion of PINX1 significantly increases telomerase activity and may lead to tumorigenicity of cancer cells. This suggests that PINX1 acts as a tumor suppressor and can inhibit cell proliferation. In addition, PINX1 is involved in nucleolar RNA maturation.

Function : Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.

Subunit : Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA. 

Subcellular Location : Nucleus.

Tissue Specificity : Ubiquitous; expressed at low levels.

S端粒酶抑制因子PinX-1抗体imilarity : Belongs to the PINX1 family.

Contains 1 G-patch domain.

Database links : UniProtKB/Swiss-Prot: Q96BK5.2

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