ATP酶钙离子转运蛋白PMCA3抗体

以下为您提供的是ATP酶钙离子转运蛋白PMCA3抗体的说明书,了解更多关于ATP酶钙离子转运蛋白PMCA3抗体的英文名称,ATP酶钙离子转运蛋白PMCA3抗体别名,ATP酶钙离子转运蛋白PMCA3抗体规格,请看以下详细介绍.

英文名称  Anti-PMCA3/Calcium Pump PMCA3 ATPase 

中文名称  ATP酶钙离子转运蛋白PMCA3抗体 

别    名  ATP2B3; ATP2B3 protein; ATPase Ca++ transporting plasma membrane 3; Plasma membrane calcium ATPase 3; Plasma membrane calcium ATPase isoform 3; Plasma membrane calcium pump isoform 3; Plasma membrane calcium transporting ATPase 3; PMCA 3; PMCA3; PMCA3a; AT2B3_HUMAN. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep

ATP酶钙离子转运蛋白PMCA3抗体的多样性：

抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。

因为抗体具有与抗原决定簇相对应的结合部位（抗原结合簇），所以抗体与抗原的结合具有特异性。另一方面，抗体本身是一种蛋白质，具有本身的氨基酸组成、排列和立体结构，对异种动物来说，它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性，它们表现出不同的血清学类型。

ATP酶钙离子转运蛋白PMCA3抗体的相关产品:

Rabbit Anti-human sIgA/Alexa Fluor 488  Alexa Fluor 488标记的兔抗人分泌型IgA 0.1ml

Rabbit Anti-human sIgA/Alexa Fluor 555  Alexa Fluor 555标记的兔抗人分泌型IgA 0.1ml

Rabbit Anti-human sIgA/Alexa Fluor 647  Alexa Fluor 647标记的兔抗人分泌型IgA 0.1ml

Rabbit Anti-human sIgA/APC  APC标记的兔抗人分泌型IgA 0.1ml

产品类型  一抗    

研究领域  肿瘤 细胞生物 神经生物学 信号转导 转运蛋白  

蛋白分子量  predicted molecular weight: 134kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PMCA3/Calcium Pump PMCA3 ATPase 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Plasma membrane-type Ca2+-ATPases (PMCAs) mediate the export of bivalent calcium ions from eukaryotic cells. As members of the P class of ion-motive ATPases, PMCAs are a functionally diverse group of proteins that are derived from alternatively spliced transcripts originating from four distinct genes, PMCA1, 2, 3, and 4. The expression of different PMCA isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, and with respect to the physiological needs of specific cell and tissue types. Spatial and temporal rates of resting intracellular Ca2+ concentrations and Ca2+ signaling in eukaryotic cells are dependent on the array of PMCA isoforms that are expressed in concert with the rate of Ca2+ export. PMCA3 expression is confined to brain and skeletal muscle. The PMCA4 gene is located on human chromosome 1q25 and is ubiquitously expressed.

Function : Calcium Pump PMCA3 ATPase belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. Calcium Pump PMCA3 ATPase is the plasma membrane calcium ATPase isoform 3.

Subcellular Location : Cell membrane; Multi-pass membrane protein.

Tissue Specificity : Isoform XE and isoform XB are the most abundant isoforms and are detected at low levels in brain and fetal skeletal muscle. The other isoforms are only found at lower levels and not in fetal tissues.

ATP酶钙离子转运蛋白PMCA3抗体Similarity : Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.

Database links : UniProtKB/Swiss-Prot: Q16720.3