枯草溶菌素转化酶1抑制剂抗体

公司枯草溶菌素转化酶1抑制剂抗体具有高纯度、高效价、高特异性的特点，仅用于科学研究，不可用于临床诊断及药物治疗，可以应用于多种实验。CST、Santa抗体品牌。

英文名称  Anti-PROSAAS 

中文名称  枯草溶菌素转化酶1抑制剂抗体 

别    名  b-LEN; b-PEN-LEN; b-SAAS; Big LEN; granin like neuroendocrine peptide; l-LEN; l-SAAS; N-proSAAS; PCSK1_HUMAN; Pcsk1n; pro-SAAS; Proprotein convertase 1 inhibitor; Proprotein convertase subtilisin/kexin type 1 inhibitor; PROSAAS; SAAS; SAAS CT(1-49); SAAS CT(25-40). 

浓    度  1mg/1ml 

规 格  0.2ml/200μg
枯草溶菌素转化酶1抑制剂抗体的相关产品:

Rabbit Anti-Mink IgG/FITC  FITC标记的兔抗水貂IgG 0.3ml

Rabbit Anti-Mink IgG/Gold  胶体金标记的兔抗水貂IgG 0.5ml

Rabbit Anti-Mink IgG/HRP  辣根过氧化物酶标记的兔抗水貂IgG 0.1ml

枯草溶菌素转化酶1抑制剂抗体抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human

产品类型  一抗    

研究领域  细胞生物 神经生物学 信号转导 生长因子和激素 泛素 Alzheimer's  

蛋白分子量  predicted molecular weight: 24kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PROSAAS (34-130aa) 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 PCSK1N is a 260 amino acid protein that is both secreted and localized to the trans-Golgi network. Expressed in pancreas and brain, PCSK1N is thought to play a role in the control of the neuroendocrine secretory pathway and may also be involved in PCSK1 inhibition. The gene encoding PCSK1N maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes. In conjunction with chromosome Y, chromosome X is responsible for sex determination, as an X and a Y chromosome lead to normal male development, while two copies of an X chromosome lead to normal female development. There are a number of conditions related to an abnormal number and combination of sex chromosomes, some of which include Turner's syndrome, color blindness, hemophilia and Duchenne muscular dystrophy.

Function : May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.

Subunit : Interacts via the C-terminal inhibitory domain with PCSK1 66 kDa form

Subcellular Location : Secreted. Golgi apparatus > trans-Golgi network. A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1.

Tissue Specificity : Expressed in brain and pancreas.

枯草溶菌素转化酶1抑制剂抗体Post-translational modifications : Proteolytically cleaved in the Golgi.

O-glycosylated with a core 1 or possibly core 8 glycan.

Database links : UniProtKB/Swiss-Prot: Q9UHG2.1

公司提供枯草溶菌素转化酶1抑制剂抗体价格绝对优势，欢迎新老客户来电垂询我公司优质抗体枯草溶菌素转化酶1抑制剂抗体说明书及报价等。