蛋白酪氨酸磷酸酶受体PCPTP1抗体

公司蛋白酪氨酸磷酸酶受体PCPTP1抗体具有高纯度、高效价、高特异性的特点，仅用于科学研究，不可用于临床诊断及药物治疗，可以应用于多种实验。CST、Santa抗体品牌。

英文名称  Anti-PCPTP1 

中文名称  蛋白酪氨酸磷酸酶受体PCPTP1抗体 

别    名  Ch-1PTPase; Ch1 PTPase; DKFZp781C1038; EC PTP; ECPTP; NC PTPCOM1; NC-PTPCOM1; Protein tyrosine phosphatase Cr1PTPase precursor; Protein tyrosine phosphatase NC PTPCOM1; Protein tyrosine phosphatase PCPTP1; Protein tyrosine phosphatase receptor type R; Protein-tyrosine phosphatase PCPTP1; PTP SL; PTPBR7; PTPRQ; PTPRR; PTPRR_HUMAN; PTPSL; R-PTP-R; Receptor type tyrosine protein phosphatase R; Receptor-type tyrosine-protein phosphatase R. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg 
蛋白酪氨酸磷酸酶受体PCPTP1抗体的相关产品:

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Rabbit anti-MG IgG/PE  PE标记的兔抗长爪沙鼠IgG 0.1ml

Rabbit anti-MG IgG/PE-Cy3  PE-Cy3标记的兔抗长爪沙鼠IgG 0.1ml

蛋白酪氨酸磷酸酶受体PCPTP1抗体抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Sheep 

产品类型  一抗    

研究领域  肿瘤 细胞生物 细胞周期蛋白 细胞分化  

蛋白分子量  predicted molecular weight: 72kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PCPTP1 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 The protein tyrosine phosphatase (PTP) family of proteins are signaling molecules that regulate processes such as cell growth, cell differentiation, oncogenic transformation and the mitotic cycle. PCPTP1, also known as PTPRR (Receptor-type tyrosine-protein phosphatase R), ECPTP, PTPBR7 or PTPRQ, is a 657 amino acid protein that functions to sequester inactive mitogen-activated protein kinases (MAPKs) to the cytoplasm. Expressed primarily in the brain with weaker expression in other parts of the body, PCPTP1 is a receptor-like molecule that is able to dephosphorylate MAPKs, thereby rendering them inactive. Three isoforms of PCPTP1 exist and are designated alpha, beta and gamma. The alpha form is localized to the cell membrane, while the beta and gamma forms are localized to the perinuclear areas within the cytoplasm.

Function : Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus.

Subunit : Interacts with MAPKs

Subcellular Location : Cell membrane and Cytoplasm > perinuclear region. Locates to the perinuclear areas within the cytoplasm.

Tissue Specificity : Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus.

S蛋白酪氨酸磷酸酶受体PCPTP1抗体imilarity : Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Database links : UniProtKB/Swiss-Prot: Q15256.2

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