植烷酰辅酶A羟化酶2相互作用蛋白抗体

公司植烷酰辅酶A羟化酶2相互作用蛋白抗体具有高纯度、高效价、高特异性的特点，仅用于科学研究，不可用于临床诊断及药物治疗，可以应用于多种实验。CST、Santa抗体品牌。

英文名称  Anti-PHYHIP 

中文名称 植烷酰辅酶A羟化酶2相互作用蛋白抗体

别    名  DYRK1A interacting protein 3; DYRK1AP3; PAHX AP1; PAHXAP1; phytanoyl CoA 2 hydroxylase interacting protein; phytanoyl CoA alpha hydroxylase associated protein; Phytanoyl CoA hydroxylase associated protein 1; Phytanoyl CoA hydroxylase interacting protein; Similar to a putative C.elegans gene encoded in cosmid M01B2; PHYIP_HUMAN. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg
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植烷酰辅酶A羟化酶2相互作用蛋白抗体抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit

产品类型  一抗    

研究领域  肿瘤 心血管 神经生物学 结合蛋白  

蛋白分子量  predicted molecular weight: 38kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PHYHIP 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 PHYHIP (Phytanoyl-CoA hydroxylase-interacting protein) is a 330 amino acid protein that is strongly expressed in brain, with weak expression in ovary, small intestine and ovary. In transgenic mice, overexpression of PHYHIP in heart results in tachycardia and tachyarrhythmia. PHYHIP interacts with the Refsum disease gene product, PAHX, indicating that PHYHIP may play a role in the CNS deficits of Refsum disease, which is characterized by cerebellar degeneration, neurologic damage and peripheral neuropathies. PHYHIP also interacts with Dyrk1A, a protein that that is overexpressed in brain of Down-syndrome patients, therefore PHYHIP may participate in some of the neurological abnormalities of Down syndrome. Significantly, the gene encoding PHYHIP is localized to a region of the short arm of human chromosome 8 that is frequently found deleted in prostate, breast and several other types of cancers.

Function : PHYHIP interacts with PHYH, suggesting a role in the development of the central nervous system. It may be involved in the development of neurological abnormalities observed in Down syndrome patients.

Subunit : Interacts with PHYH and BAI1.

Subcellular Location : Protein binding

Tissue Specificity : Highly expressed in the brain.

植烷酰辅酶A羟化酶2相互作用蛋白抗体Similarity : Belongs to the PHYHIP family. 

Contains 1 fibronectin type-III domain. 

Database links : UniProtKB/Swiss-Prot: Q92561.1

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