磷酸二酯酶7B抗体

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英文名称  Anti-PDE7B 

中文名称  磷酸二酯酶7B抗体 

别    名  PDE 7B; PDE7B protein; Phosphodiesterase 7B; Phosphodiesterase7B; RNPDE7B; Rolipram insensitive phosphodiesterase type 7; bA472E5.1; cAMP specific 3 5 cyclic phosphodiesterase 7B; cAMP specific 3'5' cyclic phosphodiesterase 7B; High affinity cAMP specific 3 5 cyclic phosphodiesterase; High affinity cAMP specific 3'5' cyclic phosphodiesterase; PDE7B_HUMAN. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep

磷酸二酯酶7B抗体的多样性：

抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。

因为抗体具有与抗原决定簇相对应的结合部位（抗原结合簇），所以抗体与抗原的结合具有特异性。另一方面，抗体本身是一种蛋白质，具有本身的氨基酸组成、排列和立体结构，对异种动物来说，它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性，它们表现出不同的血清学类型。

磷酸二酯酶7B抗体的相关产品:

Rabbit Anti-mouse IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗小鼠IgG 0.1ml

Rabbit Anti-mouse IgG/PE-Cy7  PE-Cy7标记的兔抗小鼠IgG 0.1ml

Rabbit Anti-mouse IgG/RBITC  罗丹明标记的兔抗小鼠IgG 0.3ml

Rabbit Anti-mouse IgG-Fc  兔抗小鼠IgG-Fc 1mg

产品类型  一抗    

研究领域  神经生物学 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号  

蛋白分子量  predicted molecular weight: 52kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PDE7B (281-360aa) 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Phosphodiesterases (PDE, also designated cyclic nucleotide phosphodiesterase) are important for the downregulation of the intracellular level of the second messenger cyclic adenosine monophosphate (cAMP) by hydrolyzing cAMP to 5'AMP. Phosphodiesterase type 3 isoforms, PDE3A and 3B, are expressed primarily in cardiovascular tissue and adipose tissue, respectively. PDE3A, is found in myocardium and platelets and PDE3B is found in lymphocytes. The PDE7A1 (HCP1) isozyme and the PDE7A2 proteins, alternate splice products of PDE7A, are highly expressed in skeletal muscle. PDE7B is most highly expressed in pancreas. The PDE family contains proteins that serve tissue-specific roles in regulation of lipolysis, glycogenolysis, myocardial contractility, and smooth muscle relaxation.

Function : PDE7B is a cAMP specific phosphodiesterase. The cAMP-specific phosphodiesterase type-7 (PDE7) family is comprised of 2 genes (PDE7A and PDE7B) each with multiple splice variants generated by RNA splicing and use of alternate initiation sites. PDE7B has three splice variants (PDE7B1 = 446 amino acid; PDE7B2 =359 amino acids and PDE7B3 = 459 amino acids. Both PDE7B2 ad PDE7B3 posses unique N-terminal sequences. PDE7B is expressed in various tissues including skeletal muscle, heart, lung and testis. PDE7B may be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.

Tissue Specificity : Highly expressed in brain. Also expressed in heart, liver, skeletal muscle and pancreas. 

Similarity : Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 s磷酸二酯酶7B抗体ubfamily. 

Database links : UniProtKB/Swiss-Prot: Q9NP56.1