丝氨酸/苏氨酸蛋白激酶PCTK2抗体

以下为您提供的是丝氨酸/苏氨酸蛋白激酶PCTK2抗体的说明书,了解更多关于丝氨酸/苏氨酸蛋白激酶PCTK2抗体的英文名称,丝氨酸/苏氨酸蛋白激酶PCTK2抗体别名,丝氨酸/苏氨酸蛋白激酶PCTK2抗体规格,请看以下详细介绍.

英文名称  Anti-PCTAIRE2 

中文名称  丝氨酸/苏氨酸蛋白激酶PCTK2抗体 

别    名  PCTAIRE-2; PCTAIRE-motif protein kinase 2; PCTK2; Protein kinase cdc2-related PCTAIRE-2; Serine/threonine-protein kinase PCTAIRE-2; 6430598J10Rik; EC 2.7.1.37; MGC25109; CDK17_HUMAN. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep, shp

丝氨酸/苏氨酸蛋白激酶PCTK2抗体的多样性：

抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。

因为抗体具有与抗原决定簇相对应的结合部位（抗原结合簇），所以抗体与抗原的结合具有特异性。另一方面，抗体本身是一种蛋白质，具有本身的氨基酸组成、排列和立体结构，对异种动物来说，它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性，它们表现出不同的血清学类型。

丝氨酸/苏氨酸蛋白激酶PCTK2抗体的相关产品:

Rabbit Anti-mouse IgG-Fc/Alexa Fluor 555  Alexa Fluor 555标记的兔抗小鼠IgG-Fc 0.1ml

Rabbit Anti-mouse IgG-Fc/Alexa Fluor 647  Alexa Fluor 647标记的兔抗小鼠IgG-Fc 0.1ml

Rabbit Anti-mouse IgG-Fc/AP  碱性磷酸酶（AP）标记的兔抗小鼠IgG-Fc 0.1ml  

产品类型  一抗    

研究领域  细胞生物 神经生物学 信号转导 细胞周期蛋白 激酶和磷酸酶 表观遗传学  

蛋白分子量  predicted molecular weight: 60kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PCTAIRE2 (301-400aa) 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with cyclins to phosphorylate key substrates involved in cell cycle progression. Another family of proteins, Cdk inhibitors, also play a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Members of the Cdk family include Cdk2–Cdk8, PCTAIRE-1–3, PITALRE and PITSLRE. PCTAIRE-1, PCTAIRE-2 and PCTAIRE-3 comprise a subfamily of cdc2-related serine/threonine kinases. PCTAIRE-1, which is expressed primarily in mammalian brain, interacts with a variety of proteins and is thought to be part of a multiple signal transduction cascade. PCTAIRE-2, also expressed in brain, may be important in terminally differentiated neurons.

Function : PCTAIREs are members of a subfamily of Cdc2-related kinases that are preferentially expressed in post-mitotic cells. PCTAIRE 2 is specifically expressed in the brain. Within the brain, PCTAIRE 2 is concentrated in the neuronal layers of the hippocampus and olfactory bulb, which mostly consist of post-mitotic neurons. In an immunocytochemical study, immunoreactivity for PCTAIRE 2 was detected in the cell bodies and extended neurites of neurons, but not in astrocytes. The PCTAIRE 2 protein is recovered in the particulate fraction and is resistant to solubilization with non-ionic detergent, suggesting that PCTAIRE 2 might be present as a component of a large protein complex. An immunoprecipitation assay revealed that the PCTAIRE 2 is associated with Ser/Thr-phosphorylating activity for histone H1, and that its activity depends on association with a regulatory partner that can be released under high-salt conditions. These findings suggest that PCTAIRE 2 is a Ser/Thr kinase that might play a unique role in terminally differentiated neurons.

Subunit : Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7

丝氨酸/苏氨酸蛋白激酶PCTK2抗体Similarity : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Database links : UniProtKB/Swiss-Prot: Q00537.2