神经丛蛋白B3抗体

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英文名称  Anti-Plexin B3 

中文名称  神经丛蛋白B3抗体 

别    名  KIAA1206; PLEXB3; Plexin-B3; PLEXR; PLXB3_HUMAN; PLXN6; PLXNB3. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Horse

神经丛蛋白B3抗体的多样性：

抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。

因为抗体具有与抗原决定簇相对应的结合部位（抗原结合簇），所以抗体与抗原的结合具有特异性。另一方面，抗体本身是一种蛋白质，具有本身的氨基酸组成、排列和立体结构，对异种动物来说，它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性，它们表现出不同的血清学类型。

神经丛蛋白B3抗体的相关产品:

Rabbit Anti-mouse IgG-Fc/APC  APC标记的兔抗小鼠IgG-Fc 0.1ml

Rabbit Anti-mouse IgG-Fc/Bio  生物素标记的兔抗小鼠IgG-Fc 0.1ml

Rabbit Anti-mouse IgG-Fc/Cy3  Cy3标记的兔抗小鼠IgG-Fc 0.1ml

产品类型  一抗    

研究领域  细胞生物 神经生物学 细胞分化  

蛋白分子量  predicted molecular weight: 202kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human Plexin B2 (354-400aa) 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Plexins are a family of large, transmembrane receptors for multiple classes of semaphorins in vertebrates. They are widely expressed, and regions of their extracellular domain are homologus to both scatter factor receptors and semaphorin domains. Plexins may act as semaphorin receptors alone or in combination with neuropilins. Plexins are divided into four subfamilies designated plexin-A, -B, -C, and -D. Plexin-B1 and -B2 are both receptors for Sema4D, which stimulates axonal outgrowth of embryonic dorsal root ganglion neurons. . Plexin-B3 binds to Sema5A, which controls axon guidance and can initiate the intracellular signaling of the hepatocyte growth factor/scatter factor receptor Met.

Function : Receptor for SEMA5A. Plays a role in axon guidance, invasive growth and cell migration.

Subunit : Interacts (via cytoplasmic domain) with RAC1 and ARHGDIA (By similarity). Binds MET and MST1R. Interacts (via cytoplasmic domain) with FSCN1. Interacts with RIT2/RIN. May form homodimers (via Sema domain). 

Subcellular Location : Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with RIT2/RIN at the plasma membrane. 

Tissue Specificity : Detected at very low levels in several fetal tissues.

Similarity : Belongs to the plexin family.

Contains 4 IPT/TIG domains.

神经丛蛋白B3抗体Contains 1 Sema domain.

Database links : UniProtKB/Swiss-Prot: Q9ULL4.2