阿黑皮素原抗体

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英文名称  Anti-POMC 

中文名称  阿黑皮素原抗体

别    名  ACTH; Adrenocorticotropic hormone; Adrenocorticotropin; Adrenocorticotropin Hormone; Alpha Melanocyte Stimulating Hormone; Alpha MSH; Alpha-MSH; Beta Endorphin; Beta Lipotropin; Beta LPH; Beta Melanocyte Stimulating Hormone; Beta MSH; Beta-LPH; Beta-MSH; CLIP; COLI_HUMAN; Corticotropin Like Intermediary Peptide; Corticotropin lipotropin; Corticotropin lipotropin precursor; Corticotropin-lipotropin; Gamma MSH; Gamma-LPH; Gamma-MSH; Lipotropin Beta; Lipotropin Gamma; LPH; Melanotropin Alpha; Melanotropin; Melanotropin beta; Melanotropin gamma; Met Enkephalin; Met-enkephalin; MSH; NPP; POC; POMC; pro ACTH endorphin; Pro opiomelanocortin; Proopiomelanocortin; Proopiomelanocortin preproprotein. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Sheep

阿黑皮素原抗体的多样性：

抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。

因为抗体具有与抗原决定簇相对应的结合部位（抗原结合簇），所以抗体与抗原的结合具有特异性。另一方面，抗体本身是一种蛋白质，具有本身的氨基酸组成、排列和立体结构，对异种动物来说，它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性，它们表现出不同的血清学类型。

阿黑皮素原抗体的相关产品:

Rabbit Anti-mouse IgG-Fc/PE  PE标记的兔抗小鼠IgG-Fc 0.1ml

Rabbit Anti-mouse IgG-Fc/PE-Cy3  PE-Cy3标记的兔抗小鼠IgG-Fc 0.1ml

Rabbit Anti-mouse IgG-Fc/PE-CY5  PE-CY5标记的兔抗小鼠IgG-Fc 0.1ml

产品类型  一抗    

研究领域  肿瘤 细胞生物 神经生物学 信号转导 内分泌病  

蛋白分子量  predicted molecular weight: 29kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human POMC 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:50-200 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].

Function : ACTH stimulates the adrenal glands to release cortisol.

MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. 

Beta-endorphin and Met-enkephalin are endogenous opiates.

Subcellular Location : Secreted.

Tissue Specificity : ACTH and MSH are produced by the pituitary gland.

Post-translational modifications : Specific enzymatic cleavages at paired basic residues yield the different active peptides. 

O-glycosylated; reducing sugar is probably N-acetylgalactosamine.

DISEASE : Defects in POMC may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. 

Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]. Affected individuals present early-onset obesity, adrenal 阿黑皮素原抗体insufficiency and red hair.

Similarity : Belongs to the POMC family.

Database links : UniProtKB/Swiss-Prot: P01189.2