肾上腺皮质发育异常同源蛋白抗体

公司肾上腺皮质发育异常同源蛋白抗体具有高纯度、高效价、高特异性的特点，仅用于科学研究，不可用于临床诊断及药物治疗，可以应用于多种实验。CST、Santa抗体品牌。

英文名称  Anti-PTOP 

中文名称  肾上腺皮质发育异常同源蛋白抗体 

别    名  PIP1; Acd; ACD_HUMAN; Adrenocortical dysplasia protein homolog; POT1 and TIN2 organizing protein; POT1 and TIN2-interacting protein; TIN2 interacting protein 1; TINT1; TPP1. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg
肾上腺皮质发育异常同源蛋白抗体的相关产品:

Rabbit anti-mouse IgM whole serum  兔抗小鼠IgM抗血清 1ml

Rabbit Anti-mouse IgM/Alexa Fluor 350  Alexa Fluor 350标记的兔抗小鼠IgM 0.1ml

Rabbit Anti-mouse IgM/Alexa Fluor 488  Alexa Fluor 488标记的兔抗小鼠IgM 0.1ml 

肾上腺皮质发育异常同源蛋白抗体抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Sheep 

产品类型  一抗    

研究领域  细胞生物 细胞周期蛋白 表观遗传学  

蛋白分子量  predicted molecular weight: 58kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PTOP 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 This gene encodes a protein that is involved in telomerefunction. This protein is one of six core proteins in thetelosome/shelterin telomeric complex, which functions to maintaintelomere length and to protect telomere ends. Through itsinteraction with other components, this protein plays a key role inthe assembly and stabilization of this complex, and it mediates theaccess of telomerase to the telomere. Multiple transcript variantsencoding different isoforms have been found for this gene. Thisgene, which is also referred to as TPP1, is distinct from theunrelated TPP1 gene on chromosome 11, which encodestripeptidyl-peptidase I. 

Function : Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.

Subunit : Component of the shelterin complex (telosome) composed ofTERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers withPOT1. Identified in a complex with POT1 and single-strandedtelomeric DNA. Interacts with STN1/OBFC1 a肾上腺皮质发育异常同源蛋白抗体nd TINF2.

Subcellular Location : Nucleus. Chromosome, telomere.

Database links : UniProtKB/Swiss-Prot: Q96AP0.3

公司提供肾上腺皮质发育异常同源蛋白抗体价格绝对优势，欢迎新老客户来电垂询我公司优质抗体肾上腺皮质发育异常同源蛋白抗体说明书及报价等。