卷曲螺旋结构域蛋白139抗体

公司卷曲螺旋结构域蛋白139抗体具有高纯度、高效价、高特异性的特点，仅用于科学研究，不可用于临床诊断及药物治疗，可以应用于多种实验。CST、Santa抗体品牌。

英文名称  Anti-PUS10/CCDC139 

中文名称  卷曲螺旋结构域蛋白139抗体

别    名  CCDC139; Coiled coil domain containing protein 139; DOBI; FLJ32312; MGC126729; Putative tRNA pseudouridine synthase Pus10; tRNA pseudouridine 55 synthase; tRNA uridine isomerase; PUS10_HUMAN. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg
卷曲螺旋结构域蛋白139抗体 的相关产品:

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Rabbit anti-mouse Kappa light chain  兔抗小鼠k链 1mg

Rabbit anti-mouse Kappa light chain/Alexa Fluor 350  Alexa Fluor 350标记的兔抗小鼠k链 0.1ml 

卷曲螺旋结构域蛋白139抗体抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep

产品类型  一抗    

研究领域  细胞生物 信号转导 细胞凋亡 表观遗传学  

蛋白分子量  predicted molecular weight: 60kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PUS10/CCDC139 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Pseudouridination is the isomerization of uridine to pseudouridine. It is the most common posttranscriptional nucleotide modification found in RNA. It is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones which facilitate the correct folding and assembly of tRNAs.

Function : Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.

卷曲螺旋结构域蛋白139抗体Post-translational modifications : Proteolytically cleaved during TRAIL-induced cell death. Cleaved, in vitro, either by caspase-3 or caspase-8.

Similarity : Belongs to the pseudouridine synthase Pus10 family. 

Database links : UniProtKB/Swiss-Prot: Q3MIT2.1

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