公司小鼠抗p21激活激酶4抗体具有高纯度、高效价、高特异性的特点,仅用于科学研究,不可用于临床诊断及药物治疗,可以应用于多种实验。CST、Santa抗体品牌。
英文名称 Anti-PAK4
中文名称 小鼠抗p21激活激酶4抗体
别 名 p21 activated kinase 4; p21(CDKN1A) activated kinase 4; PAK 4; Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs; Serine threonine kinase PAK 4; Serine/threonine protein kinase PAK 4; Serine/threonine protein kinase PAK4; KIAA1142.
浓 度 1mg/1ml
规 格 0.2ml/200μg
小鼠抗p21激活激酶4抗体的相关产品:
RAE1 mRNA结合蛋白抗体 0.1ml
RAG1/RNF74 环指蛋白74抗体(重组激活基因1) 0.2ml
RAG2 重组激活基因2蛋白抗体 0.2ml
RAIDD CASP2凋亡相关蛋白抗体 0.1ml
小鼠抗p21激活激酶4抗体抗体来源 Mouse
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit
产品类型 一抗
研究领域 肿瘤 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
蛋白分子量 predicted molecular weight: 64kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human PAK4
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 p21-activated kinases (PAKs) belong to the family of serine/threonine kinases involved in the control of various cellular processes, including the cell cycle, dynamics of the cytoskeleton, apoptosis, oncogenic transformation, and transcription. All PAK family members are characterized by the presence of p21-binding domain. p21-activated kinases are regulated by the small GTP-binding proteins Rac and Cdc42, and lipids, which stimulate autophosphorylation and phosphorylation of exogenous substrates. Serine (Ser-474) is the likely autophosphorylation site in the kinase domain of PAK4 in vivo. Phosphospecific antibodies directed against serine 474 detect activated PAK4 on the Golgi membrane when PAK4 is co-expressed with activated Cdc42. Current data strongly implicates PAK-4 in oncogenesis. PAK4 is frequently overexpressed in human t小鼠抗p21激活激酶4抗体umor cell lines of various tissue origins.
丝氨酸/苏氨酸蛋白激酶4 (PAK4)是新发现的一类蛋白因子,在细胞信号转导过程中起很重要的作用, Pak4常在人体的多种组织器官的肿瘤细胞中呈现过表达,他的丝氨酸位点很可能是Pak4酶活性区域中的自身磷酸化位点,丝氨酸到谷氨酸位点的突变体促使其获得了酶活性。在肿瘤遗传学、细胞癌变、细胞凋亡等一些重要的细胞生物学研究中,具有重要的意义。
公司提供小鼠抗p21激活激酶4抗体价格绝对优势,欢迎新老客户来电垂询我公司优质抗体小鼠抗p21激活激酶4抗体说明书及报价等。
更多
企业名称
上海抚生实业有限公司
企业信息已认证
企业类型
信用代码
310112001171431
成立日期
2012-05-02
注册资本
50
经营范围
上海抚生实业有限公司
公司地址
上海闵行区七莘路
客服电话