缺陷性分配同源物α抗体

公司缺陷性分配同源物α抗体具有高纯度、高效价、高特异性的特点，仅用于科学研究，不可用于临床诊断及药物治疗，可以应用于多种实验。CST、Santa抗体品牌。

英文名称  Anti-PAR6 

中文名称  缺陷性分配同源物α抗体 

别    名  Par 6 partitioning defective 6 C elegans homolog alpha; Par 6 partitioning defective 6 homolog alpha C elegans; PAR 6A; PAR-6 alpha; PAR-6; PAR-6A; PAR6; PAR6A_HUMAN; PAR6alpha; PAR6C; PARD6A; Partitioning defective 6 homolog alpha; Tax interacting protein 40; Tax interaction protein 40; TAX40; TIP 40; TIP-40; TIP40. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg
缺陷性分配同源物α抗体 的相关产品:

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RanBP3  RAN结合蛋白3抗体 0.2ml

RanBP7/Importin 7  RAN结合蛋白7抗体 0.2ml

RanGAP1  RAN GTPase酶激活蛋白1抗体 0.2ml

缺陷性分配同源物α抗体抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep

产品类型  一抗    

研究领域  肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 干细胞 细胞粘附分子  

蛋白分子量  predicted molecular weight: 37kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PAR6 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Function : Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Subunit : Interacts with MAP2K5 (By similarity). Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI (By similarity). Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 ('Thr-359' phosphorylated form) and PRKCI.

Subcellular Location : Cytoplasm. Cell membrane. Cell projection > ruffle. Cell junction > tight junction. Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.

Tissue Specificity : Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.

Post-translational modifications : Phosphorylated by the TGF-beta receptor (By similarity). 

缺陷性分配同源物α抗体Similarity : Belongs to the PAR6 family. 

Contains 1 OPR domain. 

Contains 1 PDZ (DHR) domain. 

Contains 1 pseudo-CRIB domain. 

Database links : UniProtKB/Swiss-Prot: Q9NPB6.1

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