内皮细胞纤溶酶原激活抑制蛋白1抗体

公司内皮细胞纤溶酶原激活抑制蛋白1抗体具有高纯度、高效价、高特异性的特点，仅用于科学研究，不可用于临床诊断及药物治疗，可以应用于多种实验。CST、Santa抗体品牌。

英文名称  Anti-PAI1/PLANH1/Serpine 1 

中文名称 内皮细胞纤溶酶原激活抑制蛋白1抗体 

别    名  Clade E; Endothelial plasminogen activator inhibitor; Nexin; PAI 1; PAI; PAI-1; PAI1_HUMAN; PLANH1; Plasminogen activator inhibitor 1; Plasminogen activator inhibitor type 1; Serine (or cysteine) proteinase inhibitor; Serpin E1; Serpin peptidase inhibitor clade E; Serpine 1; Serpine-1;Serpine1. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg
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内皮细胞纤溶酶原激活抑制蛋白1抗体抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig 

产品类型  一抗    

研究领域  肿瘤 心血管 细胞生物 激酶和磷酸酶 肿瘤细胞生物标志物  

蛋白分子量  predicted molecular weight: 45kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PAI1/PLANH1 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. 

Function : Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.

Subunit : Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation.

Subcellular Location : Secreted.

Tissue Specificity : Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells

DISEASE : Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) . It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due 内皮细胞纤溶酶原激活抑制蛋白1抗体to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.

Similarity : Belongs to the serpin family.

Database links : UniProtKB/Swiss-Prot: P05121.1

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