蛋白质二硫键异构酶抗体

以下为您提供的是蛋白质二硫键异构酶抗体的说明书,了解更多关于蛋白质二硫键异构酶抗体的英文名称,蛋白质二硫键异构酶抗体别名,蛋白质二硫键异构酶抗体规格,请看以下详细介绍.

英文名称  Anti-PDIA2/PDI 

中文名称  蛋白质二硫键异构酶抗体

别    名  Pancreatic protein disulfide isomerase; PDA2; PDI; PDIA2; PDIP; Protein disulfide isomerase A2; Protein disulfide isomerase; Protein disulfide isomerase family A member 2; PDIA2_HUMAN. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat

蛋白质二硫键异构酶抗体的多样性：

抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。

因为抗体具有与抗原决定簇相对应的结合部位（抗原结合簇），所以抗体与抗原的结合具有特异性。另一方面，抗体本身是一种蛋白质，具有本身的氨基酸组成、排列和立体结构，对异种动物来说，它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性，它们表现出不同的血清学类型。

蛋白质二硫键异构酶抗体的相关产品:

RelB  核转录因子NFKB-RelB蛋白抗体 0.2ml

RelB  转录因子RelB蛋白抗体 0.2ml

RELM beta/CCGR  结肠癌相关基因蛋白抗体 0.2ml  

产品类型  一抗    

研究领域  肿瘤 细胞生物 免疫学  

蛋白分子量  predicted molecular weight: 56kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PDIA2/PDI 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. 

Function : Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.

Subunit : Monomer; predominantly as monomer under reducing conditions. Homodimer; disulfide-linked. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Subcellular Location : Endoplasmic reticulum lumen (By similarity).

Tissue Specificity : Highly expressed in pancreas (at protein level).

Post-translational modifications : The disulfide-linked homodimer exhibits an enhanced chaperone activity. 

Glycosylated. 

Similarity : Belongs to the protein disulfide isomerase family.

蛋白质二硫键异构酶抗体Contains 2 thioredoxin domains. 

Database links : UniProtKB/Swiss-Prot: Q13087.2