多型性腺瘤基因1蛋白抗体

以下为您提供的是多型性腺瘤基因1蛋白抗体的说明书,了解更多关于多型性腺瘤基因1蛋白抗体的英文名称,多型性腺瘤基因1蛋白抗体别名,多型性腺瘤基因1蛋白抗体规格,请看以下详细介绍.

英文名称  Anti-PLAG1 

中文名称  多型性腺瘤基因1蛋白抗体 

别    名  FGFR1/PLAG1 fusion variant 3; Pleiomorphic adenoma gene 1 protein; PSA; SGPA. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse

多型性腺瘤基因1蛋白抗体的多样性：

抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。

因为抗体具有与抗原决定簇相对应的结合部位（抗原结合簇），所以抗体与抗原的结合具有特异性。另一方面，抗体本身是一种蛋白质，具有本身的氨基酸组成、排列和立体结构，对异种动物来说，它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性，它们表现出不同的血清学类型。

多型性腺瘤基因1蛋白抗体的相关产品:

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RMND1  减数分裂同源蛋白1抗体 0.2ml

RMND5B  RMND5B蛋白抗体 0.2ml

RNA polymerase II CTD repeat YSPTSPS (phospho S2)  磷酸化RNA聚合酶II CTD抗体 0.1ml 

产品类型  一抗    

研究领域  肿瘤 免疫学 信号转导 转录调节因子  

蛋白分子量  predicted molecular weight: 56kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PLAG1 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 PLAG1 is a transcription factor whose activation results in upregulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with upregulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.

Subunit : Interacts with KPNA2, which escorts protein to the nucleus via interaction with nuclear localization signal. Interacts with E3 SUMO-protein ligase PIAS1, PIAS2 and PIAS4.

Subcellular Location : Nucleus.

Tissue Specificity : Expressed in fetal tissues such as lung, liver and kidney. Not detected or weak detection in normal adult tissues, but highly expressed in salivary gland with benign or malignant pleiomorphic adenomas with or without 8q12 abberations, with preferential occurrence in benign tumors.

多型性腺瘤基因1蛋白抗体Similarity : Belongs to the krueppel C2H2-type zinc-finger protein family. 

Contains 7 C2H2-type zinc fingers.