抑制素结合蛋白抗体

以下为您提供的是抑制素结合蛋白抗体的说明书,了解更多关于抑制素结合蛋白抗体的英文名称,抑制素结合蛋白抗体别名,抑制素结合蛋白抗体规格,请看以下详细介绍.

英文名称  Anti-IGSF1

中文名称  抑制素结合蛋白抗体

别    名  PGSF2; IGCD1; IGDC1; Immunoglobulin like domain containing protein 1; Immunoglobulin superfamily member 1; InhBP; Inhibin binding protein; KIAA0364; p120; Pituitary gland specific factor 2; IGSF1_HUMAN.

浓    度  1mg/1ml

规 格  0.2ml/200μg    

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Dog, Pig, Horse

抑制素结合蛋白抗体的多样性：

抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。

因为抗体具有与抗原决定簇相对应的结合部位（抗原结合簇），所以抗体与抗原的结合具有特异性。另一方面，抗体本身是一种蛋白质，具有本身的氨基酸组成、排列和立体结构，对异种动物来说，它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性，它们表现出不同的血清学类型。

抑制素结合蛋白抗体的相关产品:

Anti-SSTR2   生长抑素受体2抗体 0.2ml

Anti-SSTR5   生长抑素受体5抗体 0.2ml

Anti-STAT2   信号转导和转录激活因子2抗体 0.2ml

Anti-STAT3   信号转导和转录激活因子3抗体 0.1ml

产品类型  一抗    

研究领域  肿瘤 信号转导 生长因子和激素 结合蛋白  

蛋白分子量  predicted molecular weight: 80, 144kDa

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human IGSF1

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:50-200

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 IGSF1 is a highly glycolylated immunoglobulin domain-containing protein. IGSF1 has been shown to act as a coreceptor in inhibin signaling, however, it does not appear to be a high-affinity inhibin receptor by itself. May reduce or inhibit activin A signaling and is believed to be necessary in the mediation of specific effects of inhibin B on activin-stimulated transcription. IGSF1 has been found to interact with several members of the ACVR family and possibly some members of the BMPR group. There are 3 known isoforms of IGSF1, with 1 and 2 likely being multi-pass membrane proteins. Isoform 3 is believed to be expressed as a secreted form. Expression is high in pancreas, testis and fetal liver, while heart, prostate and small intestine show only moderate expression. IGSF1 may be found at very low levels in brain, muscle, thymus, ovary, colon, fetal lung and fetal kidney. Isoform 3 has been detected in pituitary gland.

Function : Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription.

Subunit : Interacts with INHA (By similarity). In PubMed:12385827 does not interact with INHA; standard receptor binding assay. Interacts with ACVR1B; the interaction appears to be ligand-dependent as it is diminished by inhibin B and activin A. Interacts with ACVR2A, ACVR2B, ACVRL1 and BMPR1B. Interacts with HECTD1.

Subcellular Location : Isoforms 1 and 2: Membrane; Multipass membrane protein (Potential). Isoform 3: Secreted.

Tissue Specificity : Highly expressed in pancreas, testis and fetal liver. Moderately expressed in heart, prostate and small intestine. Expressed at very low levels in brain, thymus, ovary, colon, fetal lung and fetal kidney. Expressed in muscle. Isoform 3 is expressed in pituitary gland.

抑制素结合蛋白抗体Similarity : Contains 12 Ig-like C2-type (immunoglobulin-like) domains.

Database links : UniProtKB/Swiss-Prot: Q8N6C5.3