公司磷酸化白介素1受体1抗体具有高纯度、高效价、高特异性的特点,仅用于科学研究,不可用于临床诊断及药物治疗,可以应用于多种实验。CST、Santa抗体品牌。
英文名称 Anti-phospho-IL-1R1(Tyr496)
中文名称 磷酸化白介素1受体1抗体
别 名 IL1 Receptor I (phospho Y496); Antigen CD121a; CD121 antigen-like family member A; CD121A; CD121a antigen; D2S1473; IL 1; IL 1R 1; IL 1R alpha; IL 1RT1; IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1; IL1 inhibitor; IL1R; IL1R1; IL1R1_HUMAN; IL1RA; IL1RN; IL1RT1; Interleukin 1 receptor alpha type 1; Interleukin 1 receptor antagonist protein (IRAP); Interleukin 1 receptor type I; Interleukin receptor 1; Interleukin-1 receptor alpha; Interleukin-1 receptor type 1; Interleukin-1 receptor type I; P80.
浓 度 1mg/1ml
规 格 0.1ml/100μg
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磷酸化白介素1受体1抗体抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse
产品类型 一抗 磷酸化抗体
研究领域 心血管 免疫学 干细胞 淋巴细胞 t-淋巴细胞 细胞因子
蛋白分子量 predicted molecular weight: 63kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human IL-1R1 around the phosphorylation site of Tyr496
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II(IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
Function : Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.
Subunit : The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP.
Subcellular Location : Membrane; Single-pass type I membrane protein. Cell membrane (Probable). Secreted.
Post-translational modifications : A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).
Similarity : Belongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain.
Database links : UniProtKB/Swiss-Prot: P14778.1
磷酸化白介素1受体1抗体IL-1RⅠ属于新的信号受体家族Toll信号转导通路蛋白,IL-1RⅠ在免疫和炎症反应的研究中占重要地位,是在很多感染 、炎症性致病机制中起决定性作用的细胞因子,几乎可作用于全身各种细胞,IL-1 与IL-1R1的结合可导致大量与免疫反应和炎症相关基因的表达 ,包括细胞因子、细胞因子受体、急性期反应物、生长因子、胞外基质、粘附分子等。IL-1R1/NF-κB信号通路是机体免疫反应中十分重要的组成部分。白介素1受体I型 Interleukin 1 receptor I(IL-1RI)
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企业名称
上海抚生实业有限公司
企业信息已认证
企业类型
信用代码
310112001171431
成立日期
2012-05-02
注册资本
50
经营范围
上海抚生实业有限公司
公司地址
上海闵行区七莘路
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