公司Bipped B样蛋白抗体具有高纯度、高效价、高特异性的特点,仅用于科学研究,不可用于临床诊断及药物治疗,可以应用于多种实验。CST、Santa抗体品牌。
英文名称 Anti-IDN3
中文名称 Bipped B样蛋白抗体
别 名 CDLS; Colon tumor susceptibility 2; Delangin; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; FLJ44854; IDN 3; IDN 3 protein; IDN 3 protein isoform A; IDN 3 protein isoform B; IDN 3B; IDN3 B; IDN3 protein; IDN3 protein isoform A; IDN3 protein isoform B; IDN3B; Mis 4; Mis4; Nipbl; NIPBL_HUMAN; Nipped B homolog (Drosophila); Nipped B homolog; Nipped B like; Nipped B like protein; Nipped-B-like protein; Scc 2; SCC 2 homolog; Scc2; SCC2 homolog; Sister chromatid cohesion protein Mis
浓 度 1mg/1ml
规 格 0.2ml/200μg
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Bipped B样蛋白抗体抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep
产品类型 一抗
研究领域 心血管 细胞生物 染色质和核信号 表观遗传学
蛋白分子量 predicted molecular weight: 316kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human IDN3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function : Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity).
Subunit : Interacts directly with CBX5 via the PxVxL motif.
Subcellular Location : Nucleus (By similarity).
Tissue Specificity : Widely expressed. Highly expressed in heart, skeletal muscle, fetal and adult liver, fetal and adult kidney. Expressed at intermediates level in thymus, placenta, peripheral leukocyte and small intestine. Weakly or not expressed in brain, colon, spleen and lung.
DISEASE : Cornelia de Lange syndrome 1 (CDLS1) [MIM:122470]: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. Characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies. Bipped B样蛋白抗体Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity : Belongs to the SCC2/Nipped-B family.
Contains 5 HEAT repeats.
Database links : UniProtKB/Swiss-Prot: Q6KC79.2
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企业名称
上海抚生实业有限公司
企业信息已认证
企业类型
信用代码
310112001171431
成立日期
2012-05-02
注册资本
50
经营范围
上海抚生实业有限公司
公司地址
上海闵行区七莘路
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