发现促进癌症转移的关键蛋白质

研究者发现，癌细胞可以通过其“定居”的部位获取不同的能量来继续其转移活动，在研究过程中研究人员发现了一种名为PGC-1α的蛋白质，其是一种对细胞代谢调节异常重要的转录激活子，对于癌细胞获取能量得以生存和扩散也至关重要。

HZA228Po ELISA Kit for Anti-Mullerian Hormone (AMH) 猪抗缪勒管激素(AMH)检测试剂盒

HZA072Po ELISA Kit for Defensin Beta 2 (DEFb2) 猪防御素β2(DEFβ2)检测试剂盒

HZA212Po ELISA Kit for Matrix Metalloproteinase 23B (MMP23B) 猪基质金属蛋白酶23B(MMP23B)检测试剂盒

HZA120Po ELISA Kit for Stem Cell Factor (SCF) 猪干细胞因子(SCF)检测试剂盒

HZA123Po ELISA Kit for Transforming Growth Factor Alpha (TGFa) 猪转化生长因子α(TGFα)检测试剂盒

HZA213Po ELISA Kit for Triggering Receptor Expressed On Myeloid Cells 1 猪髓细胞触发受体1(TREM1)检测试剂盒

(TREM1)

HZA006Po ELISA Kit for Amphiregulin (AREG) 猪双调蛋白(AREG)检测试剂盒

HZA128Po ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 猪组织金属蛋白酶抑制因子2(TIMP2)检测试剂盒

(TIMP2)

HZA129Po ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 猪组织金属蛋白酶抑制因子3(TIMP3)检测试剂盒

(TIMP3)

HZA053Po ELISA Kit for Insulin Like Growth Factor Binding Protein 2 猪胰岛素样生长因子结合蛋白2(IGFBP2)检测试剂盒

(IGFBP2)

HZA214Po ELISA Kit for Caveolin 1 (CAV1) 猪窖蛋白(CAV1)检测试剂盒

HZA131Po ELISA Kit for Transforming Growth Factor Beta Induced Protein 猪转化生长因子β诱导蛋白(TGFβI)检测试剂盒

(TGFbI)

HZA130Po ELISA Kit for Tissue Inhibitors Of Metalloproteinase 4 猪组织金属蛋白酶抑制因子4(TIMP4)检测试剂盒

(TIMP4)

HZA134Po ELISA Kit for Tumor Necrosis Factor Beta (TNFb) 猪肿瘤坏死因子β(TNFβ)检测试剂盒

HZA055Po ELISA Kit for Insulin Like Growth Factor Binding Protein 4 猪胰岛素样生长因子结合蛋白4(IGFBP4)检测试剂盒

(IGFBP4)

HZA135Po ELISA Kit for Thrombopoietin (TPO) 猪血小板生成素(TPO)检测试剂盒

HZA140Po ELISA Kit for Plasminogen Activator, Urokinase (uPA) 猪尿激酶型纤溶酶原激活因子(uPA)检测试剂盒

HZA059Po ELISA Kit for Interleukin 12A (IL12A) 猪白介素12A(IL12A)检测试剂盒

HZA217Po ELISA Kit for Alpha-1-Microglobulin/Bikunin Precursor (a1M) 猪α1-微球蛋白(α1M)检测试剂盒

HZA061Po ELISA Kit for Interleukin 15 (IL15) 猪白介素15(IL15)检测试剂盒

HZA007Po ELISA Kit for Angiogenin (ANG) 猪血管生长素(ANG)检测试剂盒

HZA147Po ELISA Kit for Adiponectin Receptor 1 (ADIPOR1) 猪脂联素受体1(ADIPOR1)检测试剂盒

HZA153Po ELISA Kit for Alpha-Fetoprotein (aFP) 猪甲胎蛋白(αFP)检测试剂盒

HZA062Po ELISA Kit for Interleukin 16 (IL16) 猪白介素16(IL16)检测试剂盒

如果线粒体是厨房的话，PGC-1α就是大厨师，而ATP就是氧化磷酸化的关键组分。当某些癌细胞可以“旅行”至机体别的位点时，仍会有一部分癌细胞留存在“老巢”繁殖生长，如果有一种疗法可以阻断癌细胞的迁移，那么抑制PGC-1α或许就有可能帮助抑制癌症转移。

最后研究者表示，我们都知道癌细胞非常喜欢转移寻找新家，本文研究揭示了乳腺癌患者中，侵袭性癌细胞中PGC-1α的表达和癌症远端转移产生的相关性，为后期开发新型抗癌疗法提供了新的线索和帮助。（