用噬菌体绞杀“超级细菌”

抗生素在控制细菌性传染病上立下了汗马功劳，但它们同时也是催生“超级细菌”（superbug）的催化剂。所谓超级细菌，就是那些生长繁殖不受特定抗生素抑制的特殊细菌，这些细菌中要么含有某种抗生素抗性基因编码质粒，如甲氧西林抗性金黄色葡萄球菌（MRSA）的NDM-1以及碳青霉烯抗性肠杆菌科细菌（CRE），要么携带某种抗生素抗性突变基因，如喹诺啉（沙星类）抗性的出血性大肠杆菌SHV-18基因。

HZB650Po ELISA Kit for Major Basic Protein (MBP) 猪主要碱性蛋白(MBP)检测试剂盒

HZA225Po ELISA Kit for Atrial Natriuretic Peptide (ANP) 猪心钠肽(ANP)检测试剂盒

HZA172Po ELISA Kit for Platelet Factor 4 (PF4) 猪血小板因子4(PF4)检测试剂盒

HZA164Po ELISA Kit for Ubiquitin (Ub) 猪泛素(Ub)检测试剂盒

HZA164Si ELISA Kit for Ubiquitin (Ub) 猴泛素(Ub)检测试剂盒

CEA968Po ELISA Kit for Aprotinin (AP) 猪抑肽酶(AP)检测试剂盒

HZA263Po ELISA Kit for Creatine Kinase, Mitochondrial 1A (CKMT1A) 猪线粒体肌酸激酶1A(CKMT1A)检测试剂盒

HZA083Po ELISA Kit for Leptin Receptor (LEPR) 猪瘦素受体(LEPR)检测试剂盒

HZA085Po ELISA Kit for Leukemia Inhibitory Factor (LIF) 猪白血病抑制因子(LIF)检测试剂盒

HZA088Po ELISA Kit for Monocyte Chemotactic Protein 2 (MCP2) 猪单核细胞趋化蛋白2(MCP2)检测试剂盒

HZA267Po ELISA Kit for Cathepsin K (CTSK) 猪组织蛋白酶K(CTSK)检测试剂盒

HZA274Po ELISA Kit for Insulin Like Growth Factor Binding Protein 6 猪胰岛素样生长因子结合蛋白6(IGFBP6)检测试剂盒

(IGFBP6)

HZA093Po ELISA Kit for Macrophage Inflammatory Protein 1 Beta (MIP1b) 猪巨噬细胞炎性蛋白1β(MIP1β)检测试剂盒

HZA095Po ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) 猪巨噬细胞炎性蛋白3α(MIP3α)检测试剂盒

HZA096Po ELISA Kit for Macrophage Inflammatory Protein 3 Beta (MIP3b) 猪巨噬细胞炎性蛋白3β(MIP3β)检测试剂盒

CEA097Po ELISA Kit for Matrix Metalloproteinase 1 (MMP1) 猪基质金属蛋白酶1(MMP1)检测试剂盒

HZA098Po ELISA Kit for Matrix Metalloproteinase 10 (MMP10) 猪基质金属蛋白酶10(MMP10)检测试剂盒

HZA277Po ELISA Kit for Connexin 43 (CX43) 猪间隙连接蛋白43(CX43)检测试剂盒

HZA099Po ELISA Kit for Matrix Metalloproteinase 13 (MMP13) 猪基质金属蛋白酶13(MMP13)检测试剂盒

HZA302Po ELISA Kit for Galectin 2 (GAL2) 猪半乳糖凝集素2(GAL2)检测试剂盒

HZA304Po ELISA Kit for Galectin 4 (GAL4) 猪半乳糖凝集素4(GAL4)检测试剂盒

HZA519Po ELISA Kit for Apolipoprotein A1 (APOA1) 猪载脂蛋白A1(APOA1)检测试剂盒

HZA308Po ELISA Kit for Galectin 8 (GAL8) 猪半乳糖凝集素8(GAL8)检测试剂盒

HZA250Po ELISA Kit for Trypsin (TRY) 猪胰蛋白酶(TRY)检测试剂盒

HZA321Po ELISA Kit for Galectin 1 (GAL1) 猪半乳糖凝集素1(GAL1)检测试剂盒

HZA322Po ELISA Kit for Matrix Metalloproteinase 15 (MMP15) 猪基质金属蛋白酶15(MMP15)检测试剂盒

聪明的读者大概想到了，这个方法并不是让天然噬菌体来杀死细菌，而是利用细菌抑制噬菌体感染的原理让细菌“自杀”，只不过是利用基因工程细菌和噬菌体把CRISPR引入到部分菌体中，并传播至整个细菌群体。目前已在大蜡螟中完成了活体杀菌试验，下一步将在小鼠中评价其杀菌效果。不过，这种技术何时用于人体还有待时日，可能的方式是通过益生菌引入肠道