RAS癌基因相关蛋白RAB17抗体

英文名称    Rab17    

中文名称    RAS癌基因相关蛋白RAB17抗体    

别    名    Rab 17; Rab17; RAB17 member RAS oncogene family; RAB17_HUMAN; Ras related protein Rab 17; Ras related protein Rab17; Ras-related protein Rab-17; FLJ12538; OTTHUMP00000164417; OTTHUMP00000202805.    

RAS癌基因相关蛋白RAB17抗体       

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  信号转导  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    23kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Rab17    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

RAS癌基因相关蛋白RAB17抗体产品介绍    background:
Rab17 belongs to the Rab family of small Ras-like GTPases. It is specifically expressed in epithelial cells and is upregulated during cell polarization. Immunofluorescence staining studies indicate that Rab17 is associated with the perinuclear recycling endosome in nonpolarized epithelial cells and with the apical recycling endosome in polarized epithelial cells. The function of Rab17 remains unclear. Reports of Rab17 colocalization with internalized IgA in the apical endosome suggest that it may regulate receptor-mediated transcytosis. Rab17 has also been shown to regulate melanocytic filopodia formation and melanosome trafficking. siRNA knockdown of Rab17 in melanoma cells induces melanosome accumulation in the cell periphery.

Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration. 

Subcellular Location:
Recycling endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Cell projection, dendrite (By similarity). Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine (By similarity). 

Tissue Specificity:
Expressed in melanocytes (at protein level).

Similarity:
Belongs to the small GTPase superfamily. Rab family.

Database links:
UniProtKB/Swiss-Prot: Q9H0T7.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

RAS癌基因相关蛋白RAB17抗体

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