维甲酸诱导蛋白1抗体

英文名称    RAI1    

中文名称    维甲酸诱导蛋白1抗体    

别    名    DKFZP434A139; KIAA1820; MGC12824; retinoic acid induced 1; Retinoid acid induced protein 1; SMCR; SMS; RAI1_HUMAN.    

维甲酸诱导蛋白1抗体     

说 明 书    0.1ml  0.2ml      

研究领域    神经生物学  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    203kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RAI1/Retinoid acid induced protein 1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

维甲酸诱导蛋白1抗体   产品介绍    background:
Retinoic acid induced 1 (RAI1) is a 1,906 amino acid protein containing an N-terminal polyglutamine stretch that is expressed in most tissues, with highest expression in neuronal tissues. RAI1 functions as a transcriptional regulator and is important for embryonic and postnatal developments. Heterozygous deletions of the RAI1 gene are associated with Smith-Magenis syndrome (SMS), a mental retardation syndrome with behavioral, neurological and skeletal anomalies. Individuals affected with SMS usually display self-injurious behaviors, sleep disturbance, developmental delay and reduced motor and cognitive skills. RAI1 haploinsufficiency is specifically responsible for the obesity and craniofacial symptoms of SMS. RAI1 mutations have also been implicated in schizophrenia and spinocerebellar ataxia type 2.

Function:
RAI1 (retinoid-acid induced protein 1) may be involved in neuronal differentiation. RAI1 is highly similar to its mouse counterpart and is expressed at high levels mainly in neuronal tissues. RAI1 has a polymorphic polyglutamine tract in it's N-terminal domain. Expression of the mouse counterpart in neurons is induced by retinoic acid. The RAI1 gene is associated with both the severity of the phenotype and the response to medication in schizophrenic patients. Defects in RAI1 are a cause of Smith-Magenis syndrome (SMS). There are four named isoforms.

Subcellular Location:
Cytoplasmic and Nuclear. In neurons it is localized to neurites.

Tissue Specificity:
Expressed in all tissues examined with higher expression in the heart and brain. No expression was seen in the corpus callosum of the brain. 

DISEASE:
Defects in RAI1 are a cause of Smith-Magenis syndrome (SMS) [MIM:182290]. SMS is characterized by congenital mental retardation associated with development and growth delays. Affected persons have characteristic behavioral abnormalities, including self-injurious behaviors and sleep disturbance, and distinct craniofacial and skeletal anomalies. 

Similarity:
Contains 1 PHD-type zinc finger.

Database links:

Entrez Gene: 10743 Human

Omim: 607642 Human

SwissProt: Q7Z5J4 Human

Unigene: 655395 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

维甲酸诱导蛋白1抗体   

hz-0904PA Melamine/OVA(ovalbumin)  三聚氰胺与鸡卵白蛋白偶联物

hz-0971PB chloramphenicol/BSA  氯霉素偶联牛血清白蛋白

hz-0971PA chloramphenicol/OVA  氯霉素偶联鸡卵白蛋白蛋白

hz-0972PB Gentamicin/BSA  庆大霉素偶联牛血清白蛋白

hz-0972PA Gentamicin/OVA  庆大霉素偶联鸡卵白蛋白

hz-0973PB Tetracycline/BSA  四环素偶联牛血清白蛋白

hzF-0972 Gentamicin/FITC  荧光素标记庆大霉素

hz-0973PA Tetracycline/OVA  四环素偶联鸡卵白蛋白

hz-0974PB Oxytetracycline/BSA  土霉素偶联牛血清白蛋白

hz-0974PA Oxytetracycline/OVA  土霉素偶联鸡卵白蛋白

hz-2037PK streptomycin/OVA  链霉素偶联血蓝蛋白

hz-2036PB Penicillin G/BSA  青霉素G偶联牛血清白蛋白

hz-2036PA Penicillin G/OVA  青霉素G偶联鸡卵白蛋白

hz-2037PB streptomycin/BSA  链霉素偶联牛血清白蛋白

hz-2037PA streptomycin/OVA  链霉素偶联鸡卵白蛋白

hz-2059PA Metronidazole/OVA  甲硝唑偶联鸡卵白蛋白

hz-2059PB Metronidazole/BSA  甲硝唑偶联牛血清白蛋白

hz-2129PK Morphine/KLH  吗啡与血蓝蛋白偶联物

hz-2059PK Metronidazole/KLH  甲硝唑偶联牛血蓝蛋白

hz-2129PB Morphine/BSA  吗啡与牛血清白蛋白偶联物

hz-2052P TRF(transferrin)  转铁蛋白

hz-2182PA Melamine/OVA  三聚氰胺偶联鸡卵白蛋白

hz-2182PB Melamine/BSA  三聚氰胺偶联牛血清白蛋白

hz-2182PBG Melamine/Bov IgG  三聚氰胺偶联牛IgG

hz-2252PK GABA/KLH   γ1氨基丁酸偶联血蓝蛋白

hz-2252PB GABA/BSA   γ1氨基丁酸偶联牛血清白蛋白

hz-1077P OCT2 (Octamer-binding transcription factor 2)  阳离子转运蛋白2抗原

六、标记蛋白质与多肽

编  号 名  称

hz-4560PB Taurine/BSA  牛磺酸偶联牛血清白蛋白（β-氨基乙磺酸）

hz-4606PB Gibberellins/BSA  赤霉素偶联牛血清白蛋白

hzF-0326P Bovine IgG/FITC  荧光素标记牛IgG

hzF-0789P Insulin Protein/FITC  荧光素标记猪胰岛素蛋白

hzf-0327P Bovine IgM/FITC  荧光素标记牛IgM

hzF-0310P Chicken IgG/FITC  荧光素标记鸡IgG

hzf-0314P Chicken IgM/FITC  荧光素标记鸡IgM

hzf-0303P dog IgG/FITC  荧光素标记狗IgG