磷酸化心脏磷蛋白抗体

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英文名称  Anti-phospho-PLB(Ser16)

中文名称  磷酸化心脏磷蛋白抗体

别    名  Phospholamban (phospho S16); p-Phospholamban (phospho S16); p-PLB(S16); Cardiac phospholamban; CMD1P; PLB; PLN; PPLA_HUMAN.

浓    度  1mg/1ml

规 格  0.1ml/200μg

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Rabbit

产品类型  一抗  磷酸化抗体  

研究领域  心血管 免疫学 信号转导 转录调节因子 通道蛋白 细胞表面分子 线粒体  

蛋白分子量  predicted molecular weight: 5.7kDa

性    状  Lyophilized or Liquid

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免 疫 原  KLH conjugated synthesised phosphopeptide derived from human Cardiac phospholamban around the phosphorylation site of Ser16

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) . Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in PLN are the cause of cardiomyopathy familial hypertrophic type 18 (CMH18) . CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Function : Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.

Subunit : Homopentamer. Interacts with HAX1.

Subcellular Location : Mitochondrion membrane; Single-pass membrane protein. Sarcoplasmic reticulum.

Tissue Specificity : Heart.

Post-translational modifications : Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.

DISEASE : [DISEASE] Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

[DISEASE] Defects in PLN are the cause of familial hypertrophic cardiomyopathy type 18 (CMH18) [MIM:613874]. CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant 磷酸化心脏磷蛋白抗体forms with high risk of cardiac failure and sudden cardiac death.

Similarity : Belongs to the phospholamban family.