脂肪酰辅酶A家族成员1抗体

英文名称  Anti-AACS/ACSF1 

中文名称  脂肪酰辅酶A家族成员1抗体 

别    名  Acetoacetyl-CoA synthetase; ACSF1; Acyl-CoA synthetase family member 1; Protein sur-5 homolog; AACS_HUMAN. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep   

产品类型  一抗    

脂肪酰辅酶A家族成员1抗体研究领域  细胞生物 信号转导  

蛋白分子量  predicted molecular weight: 75kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human AACS (182-228aa) 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

脂肪酰辅酶A家族成员1抗体产品介绍 ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis.

Function : Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development 

Subcellular Location : Cytoplasm, cytosol 

Tissue Specificity : Highly expressed in kidney, heart and brain, but low in liver. 

Similarity : Belongs to the ATP-dependent AMP-binding enzyme family.

Database links : UniProtKB/Swiss-Prot: Q86V21.1