FBXL21蛋白抗体

FBXL21蛋白抗体英文名称  Anti-FBXL21/FBL3B 

中文名称  FBXL21蛋白抗体 

别    名  F box and leucine rich repeat protein 21; F box and leucine rich repeat protein 3 pseudogene; F box and leucine rich repeat protein 3B; F box protein Fbl3b; F box/LRR repeat protein 21; F box/LRR repeat protein 3B; Fbl 21; FBXL 21; FBXL-21; FBL 3; FBL 3B; Fbl21; FBL3; FBL-3B; FBL 3B; FBL3B; FBXL 21; FBXL 3B; FBXL 3P; FBXL3B; FBXL3P; MGC120237; FXL21_HUMAN. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg            

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Cow, Sheep   

产品类型  一抗    

研究领域  细胞生物 免疫学 细胞周期蛋白  

蛋白分子量  predicted molecular weight: 49kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human FBXL21/FBL3B 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:50-200 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

FBXL21蛋白抗体产品介绍 FBL3B is a 434 amino acid protein encoded by the human gene FBXL21. FBL3B contains one 40 amino acid F-box region, making it a member of the F-box family. FBL3B also contains three LRR (leucine-rich) repeats. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. F-box proteins are members of a large family that regulates cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. FBL3B is a substrate-recognition component of the SCF complex that interacts with Skp1 p19 and CUL-1. FBL3B is also associated with expression and regulation of circadian and cryptochrome proteins.

Function : Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex involved in circadian pacemaker function. The SCF(FBXL21) complex acts by mediating ubiquitination and subsequent degradation of CRY1. Probable clock-controlled protein that plays a specific role in suprachiasmatic nucleus, SCN and pacemaker function (By similarity). 

Subunit : Interacts with CRY1 (By similarity). Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1. 

Similarity : Contains 1 F-box domain. 

Contains 7 LRR (leucine-rich) repeats. 

Database links : UniProtKB/Swiss-Prot: Q9UKT6.1