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跨膜通道蛋白8抗体

供货周期：一周

品牌：

规格： 0.2ml/200μg

货号：

CAS号：

报价： ¥1

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产品介绍

在免疫化学技术中影响跨膜通道蛋白8抗体效率的因素主要有5个方面：①抗体对抗原的亲合性；②抗体对抗原的特异性；③抗原表位结构在该技术中是如何被改变的；④抗体与抗原结合的易接近性；⑤二级试剂的质量和类型

英文名称 Anti-EVER2/TMC8

中文名称跨膜通道蛋白8抗体

别名 epidermodysplasia verruciformis 2; Epidermodysplasia verruciformis protein 2; EV2; EVIN2; FLJ40668; FLJ43684; MGC102701; MGC40121; TMC8; Transmembrane channel like protein 8; TMC8_HUMAN.

跨膜通道蛋白8抗体浓度 1mg/1ml

规格 0.2ml/200μg

抗体来源 Rabbit

克隆类型 polyclonal

交叉反应 Human, Mouse, Rat, Cow, Horse, Sheep

产品类型一抗

研究领域肿瘤细胞生物跨膜蛋白

蛋白分子量 predicted molecular weight: 82kDa

性状 Lyophilized or Liquid

免疫原 KLH conjugated synthetic peptide derived from human EVER2/TMC8

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Transmembrane channel-like protein 8 (TMC8), also known as Epidermodysplasia verruciformis protein 2 (EVER2), is a 726 amino acid member of the TMC family of proteins. Localized to the endoplasmic reticulum membrane, TMC8 is thought to form a transmembrane channel-like protein with eight predicted transmembrane domains and three leucine zipper motifs. Mutations in the genes encoding TMC8 and TMC6, another member of the TMC family, have been shown to cause epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. Infection by HPVs lead to persistent wart-like or macular lesions. TMC8 is expressed in placenta, prostate and testis, and three named isoforms exist as a result of alternative splicing events.

Function : Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc. At least two isoforms of EVER2 are known to exist.

Subcellular Location : Endoplasmic reticulum membrane; Multi pass membrane protein.

Tissue Specificity : Expressed in placenta, prostate and testis.

DISEASE : Defects in TMC8 are a cause of epidermodysplasia verruciformis (EV) [MIM:226400]. It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions.

Similarity : Belongs to the TMC family.

Database links : UniProtKB/Swiss-Prot: Q8IU68.1

半个多世纪以来，抗体一直作为常用的研究工具，因此对其使用和储存已有丰富的经验。这些经验让人们知道如何对抗体进行操作，由于抗体的稳定性好，使用并不困难。抗体较其他蛋白不易变性，易于存放、纯化和标记。蛋白G和蛋白A等抗体结合蛋白的发现使得这项工作更具可行性。

选择合适的抗体对免疫化学技术的成功极为重要。没有任何一种来源的抗体能够满足本书所述的各种方法的要求。为了研究某一重要的抗原，应选用具有不同特性的多种抗体。在没有一套良好特性的抗体可用于研究机体中每一种蛋白之前，选择及制备适合各种技术要求的抗体非常必要。

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J00862 人组织蛋白酶抗体(Cath Ab)ELISA试剂盒 Human Cathepsin Antibodies,Cath Ab ELISA Kit 96T/48T

J00863 人乳铁传递蛋白/乳铁蛋白抗体IgG(LF/LTF Ab-Ig)ELISA试剂盒 Human Lactoferrin antibody IgG,LF/LTF Ab-IgG ELISA Kit 96T/48T

J00864 人抗杀菌通透性增高蛋白抗体(BPI-Ab)ELISA试剂盒 Human anti-Bactericidal permeability increasing protein antibody,BPI-Ab ELISA Kit 96T/48T

J00865 人髓过氧化物酶特异性抗中性粒细胞胞质抗体IgG(MPO-ANCA IgG)ELISA试剂盒 Human Mouse myeloperoxidase-antineutrophil cytoplasmic antibody IgG,MPO-ANCA IgG ELISA Kit 96T/48T

J00866 人抗蛋白酶3抗体IgG(PR3 Ab-IgG)ELISA试剂盒 Human Anti-proteinase 3 antibody IgG,PR3 Ab-IgG ELISA Kit 96T/48T

J00867 人抗α-胞衬蛋白抗体IgG/IgA(α-Fodrin IgG/IgA)ELISA试剂盒 Human anti-alpha-Fodrin IgG/IgA,α-Fodrin IgG/IgA ELISA Kit 96T/48T

J00868 人抗单链DNA抗体/变性DNA抗体(ssDNA)ELISA试剂盒 human single stranded DNA Antibody,ssDNA ELISA Kit 96T/48T

J00869 人抗组蛋白(H2A-H2B)-DNA抗体/抗二聚体-DNA抗体ELISA试剂盒 Human histone H2A-H2B-DNA autoantibody ELISA Kit 96T/48T

J00870 人抗双链DNA抗体/天然DNA抗体(dsDNA)ELISA试剂盒 Human anti-double stranded DNA,dsDNA ELISA Kit 96T/48T

J00871 人抗核小体抗体IgG(AnuA-IgG)ELISA试剂盒 human anti-nucleosome antibody IgG,AnuA-IgG ELISA Kit 96T/48T

J00872 人抗硬皮病抗体70(SCL70/topoⅠ)ELISA试剂盒 Human anti-scl70 antibody,SCL70/topoⅠELISA Kit 96T/48T

J00873 人抗SS-B/La抗体ELISA试剂盒 Human SS-B/La Antibody,ELISA Kit 96T/48T

J00874 人落叶型天疱疮抗体(PF)ELISA试剂盒 Human Pemphigus Foliaceus,PF ELISA Kit 96T/48T

J00875 人β2糖蛋白1抗体IgA(β2-GP1 Ab IgA)ELISA试剂盒 Human β2-Glycoprotein 1 antibody IgA,β2-GP1 Ab IgA ELISA Kit 96T/48T

J00876 人β2糖蛋白1抗体IgM(β2-GP1 Ab IgM)ELISA试剂盒 Human β2-Glycoprotein 1 Antibody IgM,β2-GP1 Ab IgM ELISA Kit 96T/48T

J00877 人β2糖蛋白1抗体IgG(β2-GP1 Ab IgG)ELISA试剂盒 Human β2-Glycoprotein 1 Antibody IgG,β2-GP1 Ab IgG ELISA Kit 96T/48T

J00878 人抗心磷脂抗体IgA(ACA-IgA)ELISA试剂盒 Human anti-cardiolipin antibody IgA,ACA-IgA ELISA Kit 96T/48T

J00879 人抗心磷脂抗体IgM(ACA-IgM)ELISA试剂盒 Human anti-cardiolipin antibody IgM,ACA-IgM ELISA Kit 96T/48T

J00880 人抗心磷脂抗体IgG(ACA-IgG)ELISA试剂盒 Human anti-cardiolipin antibody IgG,ACA-IgG ELISA Kit 96T/48T

J00881 人抗高尔基体抗体(AGAA)ELISA试剂盒 Human anti-golgi apparatus antibody,AGAA ELISA Kit 96T/48T

J00882 人S100钙结合蛋白A9/钙粒蛋白B(S100A9)ELISA试剂盒 human S100 calcium binding protein A9/calgranulin B,S100A9 ELISA Kit 96T/48T

J00883 人S100钙结合蛋白A8/钙粒蛋白A(S100A8)ELISA试剂盒 human S100 calcium binding protein A8/calgranulin A,S100A8 ELISA Kit 96T/48T

J00884 人前病毒整合位点1(Pim1)ELISA试剂盒 human proviral integration site 1,Pim1 ELISA Kit 96T/48T

J00885 人绿脓杆菌外毒素A(PEA)ELISA试剂盒 Human Pseudomonas Exotoxin A,PEA ELISA Kit 96T/48T

J00886 人流感病毒A(FLU A)ELISA试剂盒 Human Influenza viruses A,FLU A ELISA Kit 96T/48T

J00887 人单核细胞增多性李斯特菌素O((LLO)ELISA试剂盒 Human listeriolysin O,LLO ELISA Kit 96T/48T

J00888 人乙型肝炎病毒X抗原(HBxAg)ELISA试剂盒 Human hepatitis B virus X Ag,HBxAg ELISA Kit 96T/48T

J00889 人腺相关病毒(AAV)ELISA试剂盒 Human adeno-associated virus,AAV ELISA Kit 96T/48T

J00890 人乙型肝炎病毒X蛋白相互作用蛋白(HBXIP)ELISA试剂盒 Human hepatitis B virus X interacting protein,HBXIP ELISA Kit 96T/48T

J00891 人伤寒抗原(St-Ag)ELISA试剂盒 Human Salmonella typhi antigen,St-Ag ELISA Kit 96T/48T

J00892 人类嗜T淋巴细胞Ⅰ型病毒(HTLV-Ⅰ)ELISA试剂盒 Human T-lymphotropicvirusⅠ,HTLV-ⅠELISA Kit 96T/48T

J00893 人麻疹病毒(MV)ELISA试剂盒 Human morbillivirus,MV ELISA Kit 96T/48T

J00894 人流行性腮腺炎(EP)ELISA试剂盒 Human epidemic parotitis,EP ELISA Kit 96T/48T

J00895 人痢疾内阿米巴抗原ELISA试剂盒 Human Entamoeba histolytica Antigen ELISA Kit 96T/48T

J00896 人莱姆IgG(Lyme-IgG)ELISA试剂盒 Human Lyme IgG ELISA Kit 96T/48T

J00897 人空肠弯曲菌黏附蛋白(PEB1)ELISA试剂盒 Human Campylobacter Jejuni PEB1 ELISA Kit 96T/48T

J00898 人衣原体蛋白酶样活性因子(CPAF)ELISA试剂盒 Human chlamydial protease-like activity factor,CPAF ELISA Kit 96T/48T

J00899 人脊髓灰质炎病毒IgG(PV-IgG)ELISA试剂盒 Human Poliomyelitis Virus,PV-IgG ELISA Kit 96T/48T

J00900 人刚地弓形虫(T.gondii)ELISA试剂盒 Human Toxoplasma Gondii,T.gondii ELISA Kit 96T/48T

J00901 人抗副流感病毒IgG抗体(anti-PIV IgG )ELISA试剂盒 Human Poliomyelitis Virus,PV-IgG ELISA Kit 96T/48T

J00902 人大疱性类天疱疮抗体(BP)ELISA试剂盒 Human Bullous Pemphigoid,BP ELISA Kit 96T/48T

J00903 人肠病毒(Enterovirus)ELISA试剂盒 Human Enterovirus ELISA Kit 96T/48T

J00904 人冠状病毒(Coronaviruses IgG)ELISA试剂盒 Human Coronaviruses IgG ELISA Kit 96T/48T

J00905 人不耐热肠毒素B亚单位(LTB)ELISA试剂盒 跨膜通道蛋白8抗体Human heat-labile enterotoxin B subunit,LTB ELISA Kit 96T/48T

J00906 人阿米巴(Amebiasis)ELISA试剂盒 Human Amebiasis ELISA Kit 96T/48T

J00907 人白喉抗体(Diphtheria Ab)ELISA试剂盒 Human Diphtheria antibody ELISA Kit 96T/48T

J00908 人囊虫病抗体(CYT Ab)ELISA试剂盒 Human Cysticercosis antybody,CYT Ab ELISA Kit 96T/48T

J00909 人利什曼原虫抗体(Leishimaria Ab)ELISA试剂盒 Human Leishimaria antibody ELISA Kit 96T/48T

J00910 人瘢痕性天疱疮抗体(CP)ELISA试剂盒 Human cicatricial Pemphigoid,CP ELISA Kit 96T/48T

更多跨膜通道蛋白8抗体价格、批发价、品牌、厂家及抗体详细说明书，都可以免费咨询及索取。