泛素蛋白连接酶抗体

供货周期：一周

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规格： 0.2ml/200μg

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CAS号：

报价： ¥1

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产品介绍

泛素蛋白连接酶抗体保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Fbx32 is an E3 ubiquitin ligase that initiates ATP dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. It is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. It is also thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. Fbx32 interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD.

Function : Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.

Subunit : Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.

Subcellular Location : Cytoplasm. Nucleus. Note=Shuttles between Cytoplasm and the nucleus.

Tissue Specificity : Specifically expressed in cardiac and skeletal muscle.

Similarity : Contains 1 F-box domain.

Database links : UniProtKB/Swiss-Prot: Q969P5.1

英文名称 Anti-MAFbx/Fbx32

中文名称 泛素蛋白连接酶抗体

别名 4833442G10Rik; AI430017; Atrogin 1; Atrogin-1; ATROGIN1; Atrophy gene 1; F box only protein 32; F-box only protein 32; F-box protein 32; FBX32_HUMAN; fbxo25; FBXO32; FLJ32424; MAFbx; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein.

浓度 1mg/1ml

规格 0.2ml/200μg

抗体来源 Rabbit

克隆类型 polyclonal

交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit

产品类型一抗

研究领域细胞生物干细胞泛素

蛋白分子量 predicted molecular weight: 42kDa

泛素蛋白连接酶抗体性状 Lyophilized or Liquid

免疫原 KLH conjugated synthetic peptide derived from human MAFbx C-terminus

亚型 IgG

纯化方法 affinity purified by Protein A